Tumour budding

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Tumour budding refers to lone tumour cells or small clusters of tumour cells at the advancing front of a tumour.[1]

Microscopic

Definitions:

  • Tumour bud = 1-4 cell(s) -- at the tumour front.
  • "High-grade budding" is >=10 tumour buds in a field of 0.385 mm2.[1]

Note:

  • If the microscope has a 22 mm eye piece and...
    • A 20x objective, the field is approximately 0.950 mm2 -- to match the buds/area -- it would be 24.68 buds/0.950 mm2.
    • A 40x objective, the field is approximately 0.238 mm2 -- to match the buds/area -- it would be 6.17 buds/0.238 mm2.

Images

  • Tumour budding in CRC - intermed. mag. (WC)

  • Tumour budding in CRC - high mag. (WC)

  • Tumour budding in CRC - very high mag. (WC)

See also

References

  1. ↑ 1.0 1.1 Ueno, H.; Murphy, J.; Jass, JR.; Mochizuki, H.; Talbot, IC. (Feb 2002). "Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer.". Histopathology 40 (2): 127-32. PMID 11952856.
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