Glassy cell carcinoma
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| Glassy cell carcinoma | |
|---|---|
| Diagnosis in short | |
 Glassy cell carcinoma. H&E stain. | |
|
| |
| LM | epithelioid cells in sheets or cords with a round/oval nucleus, one or more prominent nucleoli, abundant finely vacuolated eosinophilic to amphophilic cytoplasm, distinct cell borders, inflammation - especially eosinophils |
| LM DDx | adenosquamous carcinoma of the uterine cervix, squamous carcinoma of the uterine cervix |
| Stains | PAS stain +ve (plasma membrane) |
| Site | uterine cervix |
|
| |
| Clinical history | rapid growth |
| Prevalence | rare |
| Prognosis | poor |
| Clin. DDx | other cervical tumours |
Glassy cell carcinoma, abbreviated GCC, is a rare malignancy of the uterine cervix.
General
- Rare.
- Rapid growth, poor prognosis.[1]
- Considered a subtype of adenosquamous carcinoma.[2]
Microscopic
Features:[3]
- Epithelioid cells in sheets or cords with:
- Round/oval nucleus.
- One or more prominent nucleoli.
- Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
- Distinct cell borders.
- Inflammation - esp. eosinophils.[4]
DDx:
Images
GCC - low mag. (WC)
GCC - intermed. mag. (WC)
GCC - high mag. (WC)
GCC - very high mag. (WC)
www:
- GCC - low mag. (webpathology.com).
- GCC - high mag. (webpathology.com).
- GCC - several images (upmc.edu).
Stains
See also
References
- ↑ Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix.". J Obstet Gynaecol Res 35 (3): 584-7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406.
- ↑ Kosińiska-Kaczyńska, K.; Mazanowska, N.; Bomba-Opoń, D.; Horosz, E.; Marczewska, M.; Wielgoś, M. (Dec 2011). "Glassy cell carcinoma of the cervix--a case report with review of the literature.". Ginekol Pol 82 (12): 936-9. PMID 22384631.
- ↑ Reis-Filho, JS.; Fillus Neto, J.; Schonemann, E.; Sanderson, A.; Schmitt, FC.. "Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study.". Acta Cytol 45 (3): 407-10. PMID 11393075.
- ↑ URL: http://www.webpathology.com/image.asp?n=2&Case=561. Accessed on: 4 September 2011.
- ↑ Deshpande, AH.; Kotwal, MN.; Bobhate, SK.. "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature.". Indian J Cancer 41 (2): 92-5. PMID 15318016.