Oligoastrocytoma

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Oligoastrocytoma is an uncommon neuropathology tumour that is suspected not to be a distinct entity.[1]

General

  • Mixed tumour by definition.
  • More sophisticated testing usually allows separation into oligodendroglioma or astrocytoma.[1]

Microscopic

Features:

  • Astrocytoma-like and oligodendroglioma-like:
    1. Oligodendroglioma-like cells = round nucleus, peri-nuclear clearing.
    2. Astrocytoma-like cells = non-ovoid/elongated nucleus.

DDx:

IHC

  • Oligodendroglioma-like cells: MAP2 +ve (cytoplasm).
  • Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).

Others:

  • Ki-67 ~10%. (???)
  • p53 - focally +ve. (???)
  • IDH-1 +ve. (85%)

See also

References

  1. ↑ 1.0 1.1 Sahm, F.; Reuss, D.; Koelsche, C.; Capper, D.; Schittenhelm, J.; Heim, S.; Jones, DT.; Pfister, SM. et al. (Oct 2014). "Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma.". Acta Neuropathol 128 (4): 551-9. doi:10.1007/s00401-014-1326-7. PMID 25143301.
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