Fibrosing pleuritis
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Fibrosing pleuritis, also fibrous pleurisy, is an uncommon benign condition that mimics malignant mesothelioma.
It may be referred to as cryptogenic bilateral fibrosing pleuritis, if it is bilateral.
General
- Benign.
- No asbestos exposure.[1]
Clinical:[1]
- Pleural thickening on imaging.
- Pleural effusion.
Gross
- Pleural thickening associated with a pleural effusion.
Microscopic
Features:[2]
DDx:[4]
- Mesothelioma, desmoplastic.
Note:
- Some say mesothelioma should not be diagnosed on core biopsy.[2]
IHC
- p53 -ve/+ve.
- More common in mesothelioma.[3]
See also
References
- ↑ 1.0 1.1 1.2 Buchanan, DR.; Johnston, ID.; Kerr, IH.; Hetzel, MR.; Corrin, B.; Turner-Warwick, M. (Apr 1988). "Cryptogenic bilateral fibrosing pleuritis.". Br J Dis Chest 82 (2): 186-93. PMID 3166932.
- ↑ 2.0 2.1 URL: http://www.ultrapath.org/oldsite/uscap/uscap05/meso1.html. Accessed on: 20 February 2012.
- ↑ 3.0 3.1 Mangano, WE.; Cagle, PT.; Churg, A.; Vollmer, RT.; Roggli, VL. (Aug 1998). "The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.". Am J Clin Pathol 110 (2): 191-9. PMID 9704618.
- ↑ Corson, JM. (Nov 2004). "Pathology of mesothelioma.". Thorac Surg Clin 14 (4): 447-60. doi:10.1016/j.thorsurg.2004.06.007. PMID 15559051.