Hypersensitivity

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Hypersensitivity is a thingy one may get quized on.

Gell & Goombs classification

Type (I-IV) Formal name[1] Name Example Mediator Pathology
I Immediate h. Allergic h. anaphylaxis, (atopic) bronchial asthma, allergies IgE mast cells, inflammation (esp. eosinophils), edema
II Antibody mediated h. Cytotoxic antibody dependent h. Goodpasture syndrome antibodies (IgG, IgM) (antibody-mediated) phagocytosis & lysis
III Immune complex mediated h. Immune complex mediated h. systemic lupus erythematosus antigen-antibody complex inflammation, vasculitis with fibrinoid necrosis
IV Cell-mediated h. Delayed-type hypersensitivity tuberculosis activated T cells perivascular inflammation, granulomas


Memory device ACID:[2]

  • Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.

See also

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
  2. URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.