Familial adenomatous polyposis

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Familial adenomatous polyposis, abbreviated FAP and also known as familial polyposis coli and adenomatous polyposis coli‎, is a genetic condition that predisposes to adenomatous polyps and thus invariably results in colorectal cancer.

Gardner syndrome is a subset of FAP. Both FAP and Gardner syndrome have a mutation in the FAP gene.[1]

Inheritance

  • Autosomal dominant.

Gene

  • APC gene[1] mutation.

Variants

It comes in two main flavours:

  1. FAP (no otherwise specified - the plain vanilla flavour).
    • Many polyps - typically > 100.
  2. Attenuated FAP, abbreviated AFAP.
    • Less polyps - typically 10 to 100.[2]
      • As one my think... they tend to get cancer later than (the plain vanilla) FAP.

Associations

Benign things:

Tumours:[2]

Benign tumours:[2]

Prevalence

1/11,300-37,600 in Europe.[2]

See also

References