Tumour budding
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Tumour budding refers to lone tumour cells or small clusters of tumour cells at the advancing front of a tumour.[1]
General
- Poor prognosticator in colorectal carcinoma and invasive ductal carcinoma of the breast.[2][3]
Microscopic
Definitions:
- Tumour bud = 1-4 cell(s) -- at the tumour front.
- "High-grade budding" is >=10 tumour buds in a field of 0.385 mm2.[1]
Note:
- If the microscope has a 22 mm eye piece and...
- A 20x objective, the field is approximately 0.950 mm2 -- to match the buds/area -- it would be 24.68 buds/0.950 mm2.
- A 40x objective, the field is approximately 0.238 mm2 -- to match the buds/area -- it would be 6.17 buds/0.238 mm2.
DDx:
- Poorly differentiated adenocarcinoma.
Images
Tumour budding in CRC - intermed. mag. (WC)
Tumour budding in CRC - high mag. (WC)
Tumour budding in CRC - very high mag. (WC)
See also
References
- ↑ 1.0 1.1 Ueno, H.; Murphy, J.; Jass, JR.; Mochizuki, H.; Talbot, IC. (Feb 2002). "Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer.". Histopathology 40 (2): 127-32. PMID 11952856.
- ↑ Mitrovic, B.; Schaeffer, DF.; Riddell, RH.; Kirsch, R. (Oct 2012). "Tumor budding in colorectal carcinoma: time to take notice.". Mod Pathol 25 (10): 1315-25. doi:10.1038/modpathol.2012.94. PMID 22790014.
- ↑ Gujam, FJ.; McMillan, DC.; Mohammed, ZM.; Edwards, J.; Going, JJ. (Sep 2015). "The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer.". Br J Cancer 113 (7): 1066-74. doi:10.1038/bjc.2015.287. PMID 26263482.