Sarcomatoid carcinoma of the prostate
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| Sarcomatoid carcinoma of the prostate | |
|---|---|
| Diagnosis in short | |
 Sarcomatoid carcinoma of the prostate. H&E stain. | |
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| Synonyms | sarcomatoid prostatic carcinoma |
| Subtypes | (subtype of prostate carcinoma) |
| LM DDx | sarcoma, sarcomatoid urothelial carcinoma |
| IHC | PSA +ve, keratin +ve |
| Grossing notes | prostate biopsy, prostate chips, radical prostatectomy |
| Staging | prostate cancer staging |
| Site | prostate gland - see prostate carcinoma |
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| Syndromes | see prostate carcinoma |
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| Clinical history | typically have history of conventional prostate carcinoma |
| Prevalence | uncommon |
| Prognosis | poor |
| Clin. DDx | see prostate carcinoma |
| Treatment | see prostate carcinoma |
Sarcomatoid carcinoma of the prostate, also sarcomatoid prostatic carcinoma, is a rare subtype of prostatic carcinoma with histomorphologic features suggestive of a sarcoma, and a poor prognosis.
General
Microscopic
Features:[2]
- Typically a biphasic tumour:
- Spindle cells (sarcomatous component).
- May include components of: osteosarcoma, chondrosarcoma and/or rhabdomyosarcoma.
- Epithelial (glandular) component (like conventional prostate carcinoma).
- May be absent. ‡
- Spindle cells (sarcomatous component).
Note:
- ‡ The history is should be compelling or the tumour keratin positive, if no epithelial component is present.
DDx:
Images
Sarcomatoid carcinoma:
SPC - low mag.
SPC - intermed. mag.
SPC - high mag.
SPC - very high mag.
SPC - intermed. mag.
SPC - high mag.
SPC - very high mag.
Accompanying (conventional) prostatic carcinoma:
SCP - intermed. mag.
SCP - intermed. mag.
IHC
Features - typical:[2]
- PSA +ve.
- Keratin +ve.
See also
References
- ↑ 1.0 1.1 Hansel, DE.; Epstein, JI. (Oct 2006). "Sarcomatoid carcinoma of the prostate: a study of 42 cases.". Am J Surg Pathol 30 (10): 1316-21. doi:10.1097/01.pas.0000209838.92842.bf. PMID 17001164.
- ↑ 2.0 2.1 Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 77 & 80. ISBN 978-0443066771.