Small cell carcinoma of the prostate gland
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| Small cell carcinoma of the prostate gland | |
|---|---|
| Diagnosis in short | |
 Small cell carcinoma of the prostate. H&E stain. | |
|
| |
| LM | small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common) |
| LM DDx | small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma |
| IHC | chromogranin A +ve, PSA -ve/+ve |
| Grossing notes | prostate biopsy, prostate chips, radical prostatectomy |
| Site | prostate gland - see prostate cancer |
|
| |
| Prevalence | rare |
| Prognosis | poor |
| Clin. DDx | other types of prostate cancer, metastatic cancer |
| Treatment | chemotherapy |
Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.
Neuroendocrine carcinoma of the prostate redirects to here.[1][2]
General
- Very rare.[3]
- Most common small cell carcinoma outside of the lung.[3]
- Poor prognosis.
- Not graded (ISUP 2005 consensus on Gleason grading system[4]).
Clinical:
- PSA often low in comparison to conventional prostate cancer.[3]
Microscopic
Features:
- Small cells with:
- Nuclear moulding.
- Stippled chromatin.
- High NC ratio.
- +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[3]
Notes:
- Similar to small cell carcinoma of the lung.
- High-grade squamoid component favours metastatic urothelial carcinoma.
- UCC usu. HWCK +ve.
DDx:
- Small cell carcinoma of the urinary bladder.
- Lymphoma, large cell.
- Other small round cell tumours.
Images
Case
PCNEC - very low mag. (WC)
PCNEC - low mag. (WC)
PCNEC - intermed. mag. (WC)
PCNEC - high mag. (WC)
PCNEC - low mag. (WC)
PCNEC - intermed. mag. (WC)
PCNEC - high mag. (WC)
www
- SmCC of the prostate - low mag. (webpathology.com).
- SmCC of the prostate - high mag. (webpathology.com).
- SmCC of the prostate - low mag. (nih.gov).
- SmCC of the prostate - high mag. (nih.gov).
IHC
Features:[3]
- PSA weak +ve/-ve.
- Chromogranin +ve.
See also
References
- ↑ Stein, ME.; Bernstein, Z.; Abacioglu, U.; Sengoz, M.; Miller, RC.; Meirovitz, A.; Zouhair, A.; Freixa, SV. et al. (Dec 2008). "Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network.". Am J Med Sci 336 (6): 478-88. doi:10.1097/MAJ.0b013e3181731e58. PMID 19092321.
- ↑ Alanee, S.; Moore, A.; Nutt, M.; Holland, B.; Dynda, D.; El-Zawahry, A.; McVary, KT. (Jul 2015). "Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.". Anticancer Res 35 (7): 4145-50. PMID 26124369.
- ↑ 3.0 3.1 3.2 3.3 3.4 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
- ↑ Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.