Atypical lung carcinoid tumour
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| Atypical lung carcinoid tumour | |
|---|---|
| Diagnosis in short | |
| LM DDx | small cell carcinoma of the lung, carcinoid lung tumour, pulmonary carcinoid tumourlet, lung adenocarcinoma, metastatic small cell carcinoma |
| IHC | Ki-67 ~17% (range 10-26%) |
| Site | lung - see lung tumours |
|
| |
| Clin. DDx | other lung tumours |
Atypical carcinoid lung tumour, also atypical carcinoid, is an uncommon lung tumour with a poor outcome.
General
- Approximately 20% of lung carcinoids.[1]
Microscopic
Features:[2]
- Nests of cells.
- Stippled chromatin.
- Mild-to-moderate amount of cytoplasm.
- No necrosis/focal necrosis.
- Moderate mitotic rate (2-10/HPF - definition suffers from HPFitis).
DDx:
- Typical carcinoid lung tumour.
- Small cell carcinoma of the lung.
- Metastatic small cell carcinoma.
- Lung adenocarcinoma.
IHC
- Ki-67 ~17% (range 10-26%).[3]
Note:
- Typical carcinoid is considerably lower ~2% (range 0-7%) and large cell neuroendocrine considerable higher ~81% (range 63-92%).[3]
See also
References
- ↑ Naalsund, A.; Rostad, H.; Strøm, EH.; Lund, MB.; Strand, TE. (Apr 2011). "Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study.". Eur J Cardiothorac Surg 39 (4): 565-9. doi:10.1016/j.ejcts.2010.08.036. PMID 20888248.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 115. ISBN 978-0781765275.
- ↑ 3.0 3.1 Liu, SZ.; Staats, PN.; Goicochea, L.; Alexiev, BA.; Shah, N.; Dixon, R.; Burke, AP. (2014). "Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.". Diagn Pathol 9: 174. doi:10.1186/s13000-014-0174-z. PMID 25318848.