Intratumoural lymphocytic response in colorectal carcinoma
Jump to navigation
Jump to search
This article deals with intratumoural lymphocytic response in colorectal carcinoma. It is usually just referred as intratumoural lymphocytic response.
It is also known as tumour-infiltrating lymphocytes, abbreviated TILs.
General
- Finding is suggestive of microsatellite instability.[1]
- May be seen in the context of Lynch syndrome.
Microscopic
Features:
- >10 lymphocytes/0.94 mm2.[2] †
Note:
- † Greenson et al. says >2 lymphocytes/HPF, where 5 HPF are sampled. Since the sample area given by Greenson et al. is 0.94 mm2, their field diameter is ~ 0.4892 mm. This field diameter corresponds to a 20 mm eye piece (0.4892 mm * 40x = 19.57 mm).
- Many microscopes in use today have a field diameter at 40x of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm2.
- †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".[4]
Images
www:
See also
References
- ↑ Iacopetta, B.; Grieu, F.; Amanuel, B. (Dec 2010). "Microsatellite instability in colorectal cancer.". Asia Pac J Clin Oncol 6 (4): 260-9. doi:10.1111/j.1743-7563.2010.01335.x. PMID 21114775.
- ↑ 2.0 2.1 Greenson, JK.; Bonner, JD.; Ben-Yzhak, O.; Cohen, HI.; Miselevich, I.; Resnick, MB.; Trougouboff, P.; Tomsho, LD. et al. (May 2003). "Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability.". Am J Surg Pathol 27 (5): 563-70. PMID 12717242.
- ↑ 3.0 3.1 Garg, K.; Soslow, RA. (Aug 2009). "Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma.". J Clin Pathol 62 (8): 679-84. doi:10.1136/jcp.2009.064949. PMID 19638537.
- ↑ Ropponen, KM.; Eskelinen, MJ.; Lipponen, PK.; Alhava, E.; Kosma, VM. (Jul 1997). "Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer.". J Pathol 182 (3): 318-24. doi:10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6. PMID 9349235.
- ↑ Ross, JS.; Torres-Mora, J.; Wagle, N.; Jennings, TA.; Jones, DM. (Sep 2010). "Biomarker-based prediction of response to therapy for colorectal cancer: current perspective.". Am J Clin Pathol 134 (3): 478-90. doi:10.1309/AJCP2Y8KTDPOAORH. PMID 20716806.