Carcinosarcoma

Carcinosarcoma is a tumour with a malignant epithelial component (carcinoma) and a malignant mesenchymal component (sarcoma), based on the histomorphology.

They can arise in a number of sites:

Uterine carcinosarcoma (most common).
Ovarian carcinosarcoma.
Fallopian tube carcinosarcoma.

Relation of carcinosarcoma to metaplastic carcinoma and sarcomatoid carcinoma

Carcinosarcoma implies that the tumour arose from mesenchymal cells and epithelial cells simultaneously.

This is in contradistinction to:

Sarcomatoid carcinoma - implies the tumour arose from epithelial cells only and is sarcoma-like (morphologically), and
Metaplastic carcinoma - implies the tumour arose from epithelial cells that had undergone a (morphologic) transformation (metaplasia).

Uterine carcinosarcomas are generally considered metaplastic carcinomas.^[1]^[2] They typically metastasize as carcinomas,^[3] and putatively arise from epithelial cells (only).

The term carcinosarcoma is from the morphologic era of pathology;^{[citation needed]} it precedes the modern battery of molecular tests and immunohistochemistry.

References

↑ Cantrell, LA.; Blank, SV.; Duska, LR. (Jun 2015). "Uterine carcinosarcoma: A review of the literature.". Gynecol Oncol 137 (3): 581-588. doi:10.1016/j.ygyno.2015.03.041. PMID 25805398.
↑ Artioli, G.; Wabersich, J.; Ludwig, K.; Gardiman, MP.; Borgato, L.; Garbin, F. (Apr 2015). "Rare uterine cancer: carcinosarcomas. Review from histology to treatment.". Crit Rev Oncol Hematol 94 (1): 98-104. doi:10.1016/j.critrevonc.2014.10.013. PMID 25468677.
↑ Lopez-Garcia, MA.; Palacios, J. (Nov 2010). "Pathologic and molecular features of uterine carcinosarcomas.". Semin Diagn Pathol 27 (4): 274-86. PMID 21309261.

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[pmid25805398-1] Cantrell, LA.; Blank, SV.; Duska, LR. (Jun 2015). "Uterine carcinosarcoma: A review of the literature.". Gynecol Oncol 137 (3): 581-588. doi:10.1016/j.ygyno.2015.03.041. PMID 25805398.

[pmid25468677-2] Artioli, G.; Wabersich, J.; Ludwig, K.; Gardiman, MP.; Borgato, L.; Garbin, F. (Apr 2015). "Rare uterine cancer: carcinosarcomas. Review from histology to treatment.". Crit Rev Oncol Hematol 94 (1): 98-104. doi:10.1016/j.critrevonc.2014.10.013. PMID 25468677.

[pmid21309261-3] Lopez-Garcia, MA.; Palacios, J. (Nov 2010). "Pathologic and molecular features of uterine carcinosarcomas.". Semin Diagn Pathol 27 (4): 274-86. PMID 21309261.

[1]

[2]

[3]

Carcinosarcoma

Relation of carcinosarcoma to metaplastic carcinoma and sarcomatoid carcinoma

See also

References

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