Myoepithelioma
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Myoepithelioma is a tumour of the head and neck.
General
- Usually benign.
- May be malignant.[1]
Location - head and neck:[2]
- Parotid gland ~50%.
- Palate ~25%
- Submandibular gland ~12%.
Notes:
Microsopic
Features:[5]
- Myoepithelial cells - may be:
- Spindled.
- Plasmacytoid.
- Epithelioid.
- Clear (rare).
- Lack tubules, i.e. epithelial component.
- May be up to 10% (or 5%[6]).
DDx:
Images
Myoepithelioma - low mag. (WC/Nephron)
Myoepithelioma - intermed. mag. (WC/Nephron)
Myoepithelioma - high mag. (WC/Nephron)
Myoepithelioma - very high mag. (WC/Nephron)
IHC
Features:[5]
- S100 +ve.
- GFAP +ve.
- CK14 +ve.
- Ki-67 low.
Others:[7]
- SMA +ve.
- Calponin +ve.
See also
References
- ↑ Nagao, T.; Sugano, I.; Ishida, Y.; Tajima, Y.; Matsuzaki, O.; Konno, A.; Kondo, Y.; Nagao, K. (Oct 1998). "Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases.". Cancer 83 (7): 1292-9. PMID 9762928.
- ↑ Barnes, L.; Appel, BN.; Perez, H.; El-Attar, AM. (Jan 1985). "Myoepithelioma of the head and neck: case report and review.". J Surg Oncol 28 (1): 21-8. PMID 2982059.
- ↑ Saksela, E.; Tarkkanen, J.; Wartiovaara, J. (Sep 1972). "Parotid clear-cell adenoma of possible myoepithelial origin.". Cancer 30 (3): 742-8. PMID 5075358.
- ↑ Kutzner, H.; Mentzel, T.; Kaddu, S.; Soares, LM.; Sangueza, OP.; Requena, L. (Mar 2001). "Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.". Am J Surg Pathol 25 (3): 348-55. PMID 11224605.
- ↑ 5.0 5.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 130. ISBN 978-0470519035.
- ↑ I. Weinreb. 24 October 2011.
- ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 18. ISBN 978-0470519035.