Smooth muscle tumour of uncertain malignant potential
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Smooth muscle tumour of uncertain malignant potential, abbreviated STUMP is smooth muscle lesion in which the behaviour (benign vs. malignant) cannot be ascertained with certainty.
General
- Like ASAP and ASCUS - a waffle category... when one isn't sure it is a leiomyoma vs. leiomyosarcoma.
- Clinical behaviour in uterus: usually benign.[1]
- Can be subclassified into four groups - as per Stanford.
- May be seen in the prostate gland.[2]
Management:
- Long-term follow-up.[1]
Microscopic
Features associated with recurrence:[1]
- Nuclear atypia.
DDx:
- Uterine leiomyoma.
- Leiomyosarcoma.
- See uterine leiomyosarcoma for the uterine tumour.
IHC
Features associated with recurrence:[1]
- p16 +ve.
- p53 +ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Ip PP, Cheung AN, Clement PB (July 2009). "Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases". Am. J. Surg. Pathol. 33 (7): 992–1005. doi:10.1097/PAS.0b013e3181a02d1c. PMID 19417585.
- ↑ Nagar, M.; Epstein, JI. (Jun 2011). "Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP).". Am J Surg Pathol 35 (6): 898-903. doi:10.1097/PAS.0b013e318214f2f2. PMID 21572264.