Talk:Squamous intraepithelial lesion of the uterine cervix

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UTERINE CERVIX, BIOPSY:
- SQUAMOUS INTRAEPITHELIAL LESION, FAVOUR HIGH-GRADE -- SMALL FOCUS, SEE COMMENT.
- BENIGN ENDOCERVICAL EPITHELIUM PRESENT.

COMMENT:
The cytology has intermediate features.

A p16 immunostain strongly marks the full thickness of the thin (abnormal) squamous
epithelium seen in the plane of section, and a Ki-67 focally shows positive superficial cells. These findings favour the presence of a high-grade squamous intraepithelial lesion (HSIL).

A re-biopsy with close follow-up could be considered.

Idea

UTERINE CERVIX, 12 O'CLOCK, BIOPSY:
- HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (HSIL).
- VERY SCANT STRIPPED ENDOCERVICAL EPITHELIUM.
- ACUTE AND CHRONIC INFLAMMATION.

COMMENT:
A p16 immunostain marks the full thickness of the squamous epithelium and is 
strong. A Ki-67 immunostain marks a mildly increased number of superficial 
epithelial cells. A   immunostain shows basal staining and superficial 
non-staining in the region of HSIL.
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