Leukoplakia

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Leukoplakia is a relatively common clinical finding in clinical medicine. This article looks at leukoplakia of the head and neck.

Leukoplakia. (WC/Aitor III)

Hairy leukoplakia is dealt with separately. The typical benign leukoplakia is also dealt with separately.

General

Risk of malignancy:

  • In twos series ~13% were associated with an invasive lesion.[2][3]
  • Non-homogenous leukoplakia has a greater risk of malignancy than homogenous.[3]
  • Location matters - floor of mouth and ventral tongue lesions higher risk for malignancy.[4]

Gross

  • White lesion - may be subdivided:
    • Non-homogenous.
    • Homogenous.

Microscopic

Features:[5]

DDx:

See also

References

  1. Bánóczy, J.; Gintner, Z.; Dombi, C. (Apr 2001). "Tobacco use and oral leukoplakia.". J Dent Educ 65 (4): 322-7. PMID 11336117.
  2. Lan, AX.; Guan, XB.; Sun, Z. (Jun 2009). "[Analysis of risk factors for carcinogenesis of oral leukoplakia].". Zhonghua Kou Qiang Yi Xue Za Zhi 44 (6): 327-31. PMID 19953947.
  3. 3.0 3.1 Lee, JJ.; Hung, HC.; Cheng, SJ.; Chen, YJ.; Chiang, CP.; Liu, BY.; Jeng, JH.; Chang, HH. et al. (Apr 2006). "Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors.". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101 (4): 472-80. doi:10.1016/j.tripleo.2005.07.024. PMID 16545712.
  4. Sciubba, JJ. (1995). "Oral leukoplakia.". Crit Rev Oral Biol Med 6 (2): 147-60. PMID 7548621.
  5. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 780. ISBN 0-7216-0187-1.
  6. Natarajan, E.; Woo, SB. (Jan 2008). "Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity.". J Am Acad Dermatol 58 (1): 151-7. doi:10.1016/j.jaad.2007.07.011. PMID 18158926.