Difference between revisions of "Papillary renal neoplasm with reverse polarity"
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'''Papillary renal neoplasm with reverse polarity''' is a rare [[renal tumour]] and evolving entity.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | '''Papillary renal neoplasm with reverse polarity''' is a rare [[renal tumour]] and evolving entity.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | ||
==General== | |||
*Evolving entity. | |||
*Subset of ''[[papillary renal cell carcinoma]]''. | |||
==Micro== | |||
Features:<ref name=pmid31135486/> | |||
*Branching papillae with: | |||
**Thin fibrovascular cores. | |||
**Cuboidal to columnar lining cells with granular eosinophilic cytoplasm. | |||
***May have occasional cytoplasmic clearing. | |||
**Smooth luminal borders. | |||
**Reverse polarized nuclei (luminal nuclei; nuclei closer to lumen than basement membrane). | |||
**Nucleoli absent or small. | |||
DDx: | |||
*[[Renal tumours with eosinophilic cytoplasm]]. | |||
==IHC== | ==IHC== | ||
Revision as of 21:57, 3 December 2021
Papillary renal neoplasm with reverse polarity is a rare renal tumour and evolving entity.[1]
General
- Evolving entity.
- Subset of papillary renal cell carcinoma.
Micro
Features:[1]
- Branching papillae with:
- Thin fibrovascular cores.
- Cuboidal to columnar lining cells with granular eosinophilic cytoplasm.
- May have occasional cytoplasmic clearing.
- Smooth luminal borders.
- Reverse polarized nuclei (luminal nuclei; nuclei closer to lumen than basement membrane).
- Nucleoli absent or small.
DDx:
IHC
Features:[1]
- CK7 +ve.
- CD10 +ve (all cases).
- GATA3 +ve (all cases).
- Vimentin -ve (all cases).
- CD117 -ve.
- AE1/AE3 +ve.
- EMA +ve.
- L1CAM +ve.
See also
References
- ↑ 1.0 1.1 1.2 Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ (August 2019). "Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study". Am J Surg Pathol 43 (8): 1099–1111. doi:10.1097/PAS.0000000000001288. PMID 31135486.