Difference between revisions of "Myoepithelial carcinoma"
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'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[ | '''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]]. | ||
==General== | ==General== | ||
Revision as of 01:33, 19 March 2019
Myoepithelial carcinoma, abbreviated MECA a rare malignant salivary gland tumour.[1] It is the malignant counterpart of myoepithelioma.
General
- Rare.
Microscopic
Features:
- Myoepithelial cells - may be cytologically very bland.
- +/-Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation).
- Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
- No ductal structures.
DDx:
IHC
- CAM5.2 +ve.
Molecular
- Fusions with PLAG1.[2]
See also
References
- ↑ Kong, M.; Drill, EN.; Morris, L.; West, L.; Klimstra, D.; Gonen, M.; Ghossein, R.; Katabi, N. (Jul 2015). "Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.". Am J Surg Pathol 39 (7): 931-8. doi:10.1097/PAS.0000000000000452. PMID 25970687.
- ↑ Dalin, MG.; Katabi, N.; Persson, M.; Lee, KW.; Makarov, V.; Desrichard, A.; Walsh, LA.; West, L. et al. (10 2017). "Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.". Nat Commun 8 (1): 1197. doi:10.1038/s41467-017-01178-z. PMID 29084941.