Difference between revisions of "Pneumocytoma"

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*Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref>
*Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref>
*Rare - 0.2% to 1% of lung tumours.<ref name=pmid23838116>{{Cite journal  | last1 = Salemis | first1 = NS. | last2 = Seretis | first2 = C. | last3 = Nakos | first3 = G. | last4 = Kantounakis | first4 = I. | last5 = Stoumpos | first5 = C. | last6 = Spiliopoulos | first6 = K. | title = Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. | journal = Breast Dis | volume = 34 | issue = 2 | pages = 61-5 | month = Jan | year = 2013 | doi = 10.3233/BD-130352 | PMID = 23838116 }}</ref>
*Rare - 0.2% to 1% of lung tumours.<ref name=pmid23838116>{{Cite journal  | last1 = Salemis | first1 = NS. | last2 = Seretis | first2 = C. | last3 = Nakos | first3 = G. | last4 = Kantounakis | first4 = I. | last5 = Stoumpos | first5 = C. | last6 = Spiliopoulos | first6 = K. | title = Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. | journal = Breast Dis | volume = 34 | issue = 2 | pages = 61-5 | month = Jan | year = 2013 | doi = 10.3233/BD-130352 | PMID = 23838116 }}</ref>
Management:
*Surgical excision preferred, may be followed.<ref name=pmid23838116/>


===Epidemiology===
===Epidemiology===

Revision as of 22:07, 17 February 2017

Pneumocytoma is a rare lung tumour that is typically benign. It is also known as benign sclerosing pneumocytoma.[1]

It was previously known as sclerosing hemangioma.

General

  • Derived from type 2 pneumocyte.[2]
  • Progesterone-receptor positive stromal cells.[3]
  • Rare - 0.2% to 1% of lung tumours.[4]

Management:

  • Surgical excision preferred, may be followed.[4]

Epidemiology

  • Female in 40s.[5]
  • Considered benign; excision is curative.

Gross

  • Peripheral, solitary.
  • Well-circumscribed.

Microscopic

Features:[5]

  • Mixed cell population.
  • Variable architecture:
    • Papillary.
    • Sclerotic.
    • Solid.
    • Hemorrhagic.
  • +/-Granulomas.

DDx:[8]

IHC

Features:[9]

  • EMA +ve.
  • PR +ve.[3]
  • Ki-67 membranous pattern.[10]

Negative stains:[9]

  • SMA -ve.
  • CEA -ve.
  • CD34 -ve.
  • S100 -ve.
  • Chromogranin A -ve.

Others:[2]

  • TTF-1 +ve.
  • HNF-3 alpha +ve.
  • HNF-3 beta +ve.

Sign out

Lung, Left Lower Lobe, Core Biopsy:
     - Sclerosing pneumocytoma (sclerosing hemangioma).

Comment:
The lesion stains as follows:
POSITIVE: Ki-67 (membranous pattern), TTF-1, PR.
NEGATIVE: CD56, p53.

See also

References

  1. ↑ Chan, KW.; Gibbs, AR.; Lo, WS.; Newman, GR. (Jun 1982). "Benign sclerosing pneumocytoma of lung (sclerosing haemangioma).". Thorax 37 (6): 404-12. PMID 6291188.
  2. ↑ 2.0 2.1 Yamazaki, K. (Jul 2004). "Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins.". Virchows Arch 445 (1): 45-53. doi:10.1007/s00428-004-1023-3. PMID 15138814.
  3. ↑ 3.0 3.1 Einsfelder, BM.; Müller, KM. (Sep 2005). "["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung]". Pathologe 26 (5): 367-77. doi:10.1007/s00292-005-0751-8. PMID 15731902.
  4. ↑ 4.0 4.1 Salemis, NS.; Seretis, C.; Nakos, G.; Kantounakis, I.; Stoumpos, C.; Spiliopoulos, K. (Jan 2013). "Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature.". Breast Dis 34 (2): 61-5. doi:10.3233/BD-130352. PMID 23838116.
  5. ↑ 5.0 5.1 Keylock, JB.; Galvin, JR.; Franks, TJ. (May 2009). "Sclerosing hemangioma of the lung.". Arch Pathol Lab Med 133 (5): 820-5. PMID 19415961.
  6. ↑ Pokharel, S.; Dhillon, SS.; Ylagan, L.; George, S.; Yendamuri, S. (Oct 2016). "Sclerosing Pneumocytoma with Lymph Node Metastasis.". J Thorac Oncol 11 (10): 1802-4. doi:10.1016/j.jtho.2016.06.005. PMID 27346414.
  7. ↑ Tanaka, I.; Inoue, M.; Matsui, Y.; Oritsu, S.; Akiyama, O.; Takemura, T.; Fujiwara, M.; Kodama, T. et al. (Mar 1986). "A case of pneumocytoma (so-called sclerosing hemangioma) with lymph node metastasis.". Jpn J Clin Oncol 16 (1): 77-86. PMID 3009921.
  8. ↑ URL: http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf. Accessed on: 17 June 2010.
  9. ↑ 9.0 9.1 Rodriguez-Soto, J.; Colby, TV.; Rouse, RV. (Mar 2000). "A critical examination of the immunophenotype of pulmonary sclerosing hemangioma.". Am J Surg Pathol 24 (3): 442-50. PMID 10716159.
  10. ↑ Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.
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