Difference between revisions of "Bullous diseases"
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==Pemphigus vulgaris== | ==Pemphigus vulgaris== | ||
*[[AKA]] ''pemphigus''. | |||
===General=== | ===General=== | ||
Classic presentation: | Classic presentation: | ||
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Images: | Images: | ||
*[http://www.dermpedia.org/files/images/pemphigus_vulgaris_3.jpg PV (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris]. Accessed on: 20 March 2011.</ref> | *[http://www.dermpedia.org/files/images/pemphigus_vulgaris_3.jpg PV (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris]. Accessed on: 20 March 2011.</ref> | ||
Notes: | |||
*Desmoglein 1, desmoglein 3 - abnormal. | |||
==Dermatitis herpetiformis== | ==Dermatitis herpetiformis== | ||
Revision as of 03:40, 21 March 2011
Bullous disease happens. Dermatopathologists help diagnose it.
DDx of bullous disease:[1]
- Bullous pemphigoid.
- Pemphigus vulgaris.
- Porphyria cutanea tarda.
- Dermatitis herpetiformis.
- Epidermolysis bullosa.
Bullous pemphigoid
Epidemiology
- Old people (60-80 year olds).
Pemphigus vulgaris
- AKA pemphigus.
General
Classic presentation:
- Mouth lesions.
- Non-pruritic.
Treatment:
- Prednisone then steroid sparing agent.
Epidemiology:
- Associated with thymoma, myasthenia gravis, malignancy & D-penicillamine (used to Tx Wilson's disease).
- Middle age.
Microscopic
Features:[2]
- Suprabasilar blistering.
DDx: Hailey-Hailey disease.
Images:
Notes:
- Desmoglein 1, desmoglein 3 - abnormal.
Dermatitis herpetiformis
Assoc. with celiac sprue.
Porphyria cutanea tarda
Etiology
- Genetic, autosomal dominant.
Appearance
- Vesicles/bullae in photoexposed areas subjected to trauma.
Associations
Medications/Substances:
Non-infection chronic conditions:
- DM.
Infections:
Treatment
- d/c aggravating substances (listed above), phlebotomy, hydroxychloroquine if phlebotomy contraindicated.
Epidermolysis bullosa
- Inherited, bullae & erosions from slight mechanical trauma.
See also
References
- ↑ TN07 D21-3.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1193. ISBN 978-1416031215.
- ↑ URL: http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris. Accessed on: 20 March 2011.