Difference between revisions of "Polyomavirus nephropathy"
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==IHC== | ==IHC== | ||
Features: | Features: | ||
*SV40 +ve<ref name=pmid25359127>{{Cite journal | last1 = Lautenschlager | first1 = I. | last2 = Jahnukainen | first2 = T. | last3 = Kardas | first3 = P. | last4 = Lohi | first4 = J. | last5 = Auvinen | first5 = E. | last6 = Mannonen | first6 = L. | last7 = Dumoulin | first7 = A. | last8 = Hirsch | first8 = HH. | last9 = Jalanko | first9 = H. | title = A case of primary JC polyomavirus infection-associated nephropathy. | journal = Am J Transplant | volume = 14 | issue = 12 | pages = 2887-92 | month = Dec | year = 2014 | doi = 10.1111/ajt.12945 | PMID = 25359127 }}</ref> (nuclear staining). | *[[SV40]] +ve<ref name=pmid25359127>{{Cite journal | last1 = Lautenschlager | first1 = I. | last2 = Jahnukainen | first2 = T. | last3 = Kardas | first3 = P. | last4 = Lohi | first4 = J. | last5 = Auvinen | first5 = E. | last6 = Mannonen | first6 = L. | last7 = Dumoulin | first7 = A. | last8 = Hirsch | first8 = HH. | last9 = Jalanko | first9 = H. | title = A case of primary JC polyomavirus infection-associated nephropathy. | journal = Am J Transplant | volume = 14 | issue = 12 | pages = 2887-92 | month = Dec | year = 2014 | doi = 10.1111/ajt.12945 | PMID = 25359127 }}</ref> (nuclear staining). | ||
===Images=== | ===Images=== | ||
Revision as of 17:22, 29 June 2016
Polyomavirus nephropathy is a pathology seen in renal transplants.
General
- This pathology is associated with failure of transplanted kidneys.[1]
- Treatment: reduce immunosuppression.[2]
- Implicated in urothelial carcinoma - esp. in renal transplant recipients.[3]
Microscopic
Features:[2]
- Ground glass-like nuclear inclusions.
- Nuclear enlargement.
Images
PN - high mag. (WC)
PN - very high mag. (WC)
www:
IHC
Features:
Images
PN - high mag. (WC/Nephron)
PN - very high mag. (WC/Nephron)
www:
See also
References
- ↑ Mackenzie EF, Poulding JM, Harrison PR, Amer B (1978). "Human polyoma virus (HPV)--a significant pathogen in renal transplantation". Proc Eur Dial Transplant Assoc 15: 352–60. PMID 216990.
- ↑ 2.0 2.1 Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539. Accessed on: 8 November 2010.
- ↑ Roberts, IS.; Besarani, D.; Mason, P.; Turner, G.; Friend, PJ.; Newton, R. (Nov 2008). "Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation.". Br J Cancer 99 (9): 1383-6. doi:10.1038/sj.bjc.6604711. PMID 18971934.
- ↑ URL: http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html. Accessed on: 11 November 2011.
- ↑ Lautenschlager, I.; Jahnukainen, T.; Kardas, P.; Lohi, J.; Auvinen, E.; Mannonen, L.; Dumoulin, A.; Hirsch, HH. et al. (Dec 2014). "A case of primary JC polyomavirus infection-associated nephropathy.". Am J Transplant 14 (12): 2887-92. doi:10.1111/ajt.12945. PMID 25359127.