Difference between revisions of "P16"
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[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg|thumb|right|250px|HSIL showing the characteristic p16 staining.]] | [[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg|thumb|right|250px|HSIL showing the characteristic p16 staining.]] | ||
[[Image:Endocervical adenocarcinoma in situ - p16 --- high mag.jpg|thumb|right|AIS showing the characteristic p16 staining.]] | [[Image:Endocervical adenocarcinoma in situ - p16 --- high mag.jpg|thumb|right|250px|AIS showing the characteristic p16 staining.]] | ||
'''p16''' is a commonly used [[immunostain]]. It can be considered a surrogate marker for [[HPV]] infection. | '''p16''' is a commonly used [[immunostain]]. It can be considered a surrogate marker for [[HPV]] infection. | ||
p16, like most other "p" stains, is a nuclear stain. | p16, like most other "p" stains, is a nuclear stain. | ||
Revision as of 05:24, 5 June 2016
p16 is a commonly used immunostain. It can be considered a surrogate marker for HPV infection. p16, like most other "p" stains, is a nuclear stain.
Pattern
- Nuclear stain +/- cytoplasmic staining.
Use
- Squamous lesions of the uterine cervix - see HSIL.
- Head and neck squamous cell carcinoma, specifically human papillomavirus-associated head and neck squamous cell carcinoma.
Tumours
Positive
- Squamous cell carcinoma - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC.
- High grade urothelial carcinoma ~86% of cases by PCR.[1]
Negative
- Breast carcinoma.
- Prostate carcinoma.
- Lung squamous cell carcinoma.[2]
References
- ↑ Piaton, E.; Casalegno, JS.; Advenier, AS.; Decaussin-Petrucci, M.; Mege-Lechevallier, F.; Ruffion, A.; Mekki, Y. (Oct 2014). "p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.". Cancer Cytopathol 122 (10): 760-9. doi:10.1002/cncy.21462. PMID 25069600.
- ↑ Pereira, TC.; Share, SM.; Magalhães, AV.; Silverman, JF. (Jan 2011). "Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases.". Appl Immunohistochem Mol Morphol 19 (1): 10-4. doi:10.1097/PAI.0b013e3181ecaf1c. PMID 20823766.