Difference between revisions of "Flat epithelial atypia"
Jump to navigation
Jump to search
(create w/ cat.) |
(split out) |
||
| Line 1: | Line 1: | ||
'''Flat epithelial atypia''', abbreviated '''FEA''', is a benign breast lesion that is associated with an increased risk of subsequent [[breast cancer]]. | |||
==General== | |||
Epidemiology: | |||
*Associated with [[ADH]] & [[DCIS]]; may represent a non-obligate precursor lesion of ADH & DCIS.<ref name=pmid18384213>{{Cite journal | last1 = Lerwill | first1 = MF. | title = Flat epithelial atypia of the breast. | journal = Arch Pathol Lab Med | volume = 132 | issue = 4 | pages = 615-21 | month = Apr | year = 2008 | doi = 10.1043/1543-2165(2008)132[615:FEAOTB]2.0.CO;2 | PMID = 18384213 }}</ref> | |||
*Low risk of progression to invasive malignancy.<ref name=pmid12927037>{{Cite journal | last1 = Schnitt | first1 = SJ. | title = The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance. | journal = Breast Cancer Res | volume = 5 | issue = 5 | pages = 263-8 | month = | year = 2003 | doi = 10.1186/bcr625 | PMID = 12927037 }}</ref> | |||
Management: | |||
*Excision. | |||
==Microscopic== | |||
Features: | |||
*"Flat" ~ three cells thick. | |||
*Hypercellular gland -- several layers. | |||
*Columnar cell morphology. | |||
*+/-Apical snouts. | |||
DDx: | |||
*[[Columnar cell change]]. | |||
*Columnar cell hyperplasia. | |||
*[[ADH]]. | |||
*Flat [[DCIS]] (clinging carcinoma). | |||
*Apocrine cyst - granular cytoplasm. | |||
*[[Tubular carcinoma]] - should be considered due to the association. | |||
==Images== | |||
<gallery> | |||
Image:Breast FlatAtypia (3) PA.JPG|Breast - Flat Atypia (SKB) | |||
</gallery> | |||
==Molecular== | |||
*Loss of 16q. | |||
**Not used for [[diagnosis]]. | |||
==See also== | |||
*[[Breast pathology]]. | |||
*[[Atypical ductal hyperplasia]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||
Latest revision as of 04:29, 1 May 2016
Flat epithelial atypia, abbreviated FEA, is a benign breast lesion that is associated with an increased risk of subsequent breast cancer.
General
Epidemiology:
- Associated with ADH & DCIS; may represent a non-obligate precursor lesion of ADH & DCIS.[1]
- Low risk of progression to invasive malignancy.[2]
Management:
- Excision.
Microscopic
Features:
- "Flat" ~ three cells thick.
- Hypercellular gland -- several layers.
- Columnar cell morphology.
- +/-Apical snouts.
DDx:
- Columnar cell change.
- Columnar cell hyperplasia.
- ADH.
- Flat DCIS (clinging carcinoma).
- Apocrine cyst - granular cytoplasm.
- Tubular carcinoma - should be considered due to the association.
Images
Breast - Flat Atypia (SKB)
_PA.JPG)
Molecular
- Loss of 16q.
- Not used for diagnosis.
See also
References
- ↑ Lerwill, MF. (Apr 2008). "Flat epithelial atypia of the breast.". Arch Pathol Lab Med 132 (4): 615-21. doi:10.1043/1543-2165(2008)132[615:FEAOTB]2.0.CO;2. PMID 18384213.
- ↑ Schnitt, SJ. (2003). "The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.". Breast Cancer Res 5 (5): 263-8. doi:10.1186/bcr625. PMID 12927037.