Difference between revisions of "Pneumocytoma"
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Features:<ref name=pmid10716159>{{Cite journal | last1 = Rodriguez-Soto | first1 = J. | last2 = Colby | first2 = TV. | last3 = Rouse | first3 = RV. | title = A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. | journal = Am J Surg Pathol | volume = 24 | issue = 3 | pages = 442-50 | month = Mar | year = 2000 | doi = | PMID = 10716159 }}</ref> | Features:<ref name=pmid10716159>{{Cite journal | last1 = Rodriguez-Soto | first1 = J. | last2 = Colby | first2 = TV. | last3 = Rouse | first3 = RV. | title = A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. | journal = Am J Surg Pathol | volume = 24 | issue = 3 | pages = 442-50 | month = Mar | year = 2000 | doi = | PMID = 10716159 }}</ref> | ||
*EMA +ve. | *EMA +ve. | ||
*PR +ve.<ref name=pmid15731902>{{Cite journal | *PR +ve.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref> | ||
Negative stains:<ref name=pmid10716159/> | Negative stains:<ref name=pmid10716159/> | ||
Revision as of 17:41, 15 April 2016
Pneumocytoma is a rare benign lesion of the lung. It is also known as benign sclerosing pneumocytoma.[1]
It was previously known as sclerosing hemangioma.
General
Epidemiology
- Female in 40s.[4]
- Considered benign; excision is curative.
- Rare case reports of metastases.
Gross
- Peripheral, solitary.
- Well-circumscribed.
Microscopic
Features:[4]
- Mixed cell population.
- Variable architecture:
- Papillary.
- Sclerotic.
- Solid.
- Hemorrhagic.
- +/-Granulomas.
DDx:[5]
- Papillary adenoma.
- Neuroendocrine tumour (carcinoid).
Image:
IHC
Features:[7]
- EMA +ve.
- PR +ve.[3]
Negative stains:[7]
- SMA -ve.
- CEA -ve.
- CD34 -ve.
- S100 -ve.
- Chromogranin A -ve.
Others:[2]
- TTF-1 +ve.
- HNF-3 alpha +ve.
- HNF-3 beta +ve.
See also
References
- ↑ Chan, KW.; Gibbs, AR.; Lo, WS.; Newman, GR. (Jun 1982). "Benign sclerosing pneumocytoma of lung (sclerosing haemangioma).". Thorax 37 (6): 404-12. PMID 6291188.
- ↑ 2.0 2.1 Yamazaki, K. (Jul 2004). "Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins.". Virchows Arch 445 (1): 45-53. doi:10.1007/s00428-004-1023-3. PMID 15138814.
- ↑ 3.0 3.1 Einsfelder, BM.; Müller, KM. (Sep 2005). "["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung]". Pathologe 26 (5): 367-77. doi:10.1007/s00292-005-0751-8. PMID 15731902.
- ↑ 4.0 4.1 Keylock, JB.; Galvin, JR.; Franks, TJ. (May 2009). "Sclerosing hemangioma of the lung.". Arch Pathol Lab Med 133 (5): 820-5. PMID 19415961.
- ↑ URL: http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf. Accessed on: 17 June 2010.
- ↑ URL: http://moon.ouhsc.edu/kfung/jty1/Com/Com309-1-Diss.htm. Accessed on: 14 April 2012.
- ↑ 7.0 7.1 Rodriguez-Soto, J.; Colby, TV.; Rouse, RV. (Mar 2000). "A critical examination of the immunophenotype of pulmonary sclerosing hemangioma.". Am J Surg Pathol 24 (3): 442-50. PMID 10716159.