Difference between revisions of "Serous borderline tumour"

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#redirect [[Ovarian tumours#Ovarian serous borderline tumour]]
'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].
 
It is also known as '''serous ovarian tumour of low malignant potential'''.<ref name=pmid10881733/>
 
==General==
*Usually benign.
*Require long term follow-up.
 
==Microscopic==
Features:<ref name=Ref_GP399>{{Ref GP|399}}</ref>
*Cuboidal to columnar epithelium with mild to moderate atypia.
*No invasive.
*"Sparse" mitoses.
*+/-[[Psammoma bodies]].
*+/-Micropapillary architecture - often described as a ''medusa head'' pattern.
 
DDx:
*[[Serous carcinoma of the ovary]] - focus a with stromal invasion >5mm (linear measurement) ''or'' > 10 mm<sup>2</sup> (area).<ref name=Ref_GP399>{{Ref GP|399}}</ref>
**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.
 
Images:
*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal  | last1 = Burkholz | first1 = KJ. | last2 = Wood | first2 = BP. | last3 = Zuppan | first3 = C. | title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. | journal = Radiographics | volume = 25 | issue = 6 | pages = 1689-92 | month =  | year =  | doi = 10.1148/rg.256055015 | PMID = 16284143 }}</ref>
 
===Subclassification===
Typical subdivided into:<ref name=pmid21917305>{{Cite journal  | last1 = Park | first1 = JY. | last2 = Kim | first2 = DY. | last3 = Kim | first3 = JH. | last4 = Kim | first4 = YM. | last5 = Kim | first5 = KR. | last6 = Kim | first6 = YT. | last7 = Nam | first7 = JH. | title = Micropapillary pattern in serous borderline ovarian tumors: does it matter? | journal = Gynecol Oncol | volume = 123 | issue = 3 | pages = 511-6 | month = Dec | year = 2011 | doi = 10.1016/j.ygyno.2011.08.008 | PMID = 21917305 }}</ref>
*Micropapillary serous borderline tumour.
*Typical serous borderline tumour (SBOT).
 
==Sign out==
<pre>
Cyst and Right Fallopian Tube, Excision:
    - SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
    - Fallopian tube within normal limits.
    - NEGATIVE for evidence of invasion.
 
Comment:
The lesion appears to be confined to a cystic structure.
</pre>
 
==See also==
*[[Ovarian tumours]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
[[Category:Ovarian tumours]]

Revision as of 02:07, 29 March 2016

Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.

It is also known as serous ovarian tumour of low malignant potential.[1]

General

  • Usually benign.
  • Require long term follow-up.

Microscopic

Features:[2]

  • Cuboidal to columnar epithelium with mild to moderate atypia.
  • No invasive.
  • "Sparse" mitoses.
  • +/-Psammoma bodies.
  • +/-Micropapillary architecture - often described as a medusa head pattern.

DDx:

  • Serous carcinoma of the ovary - focus a with stromal invasion >5mm (linear measurement) or > 10 mm2 (area).[2]
    • Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,[2]; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
  • Clear cell carcinoma of the ovary - classically associated with endometriosis, have simpler, smaller papillae without branching.

Images:

Subclassification

Typical subdivided into:[4]

  • Micropapillary serous borderline tumour.
  • Typical serous borderline tumour (SBOT).

Sign out

Cyst and Right Fallopian Tube, Excision:
     - SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
     - Fallopian tube within normal limits.
     - NEGATIVE for evidence of invasion.

Comment:
The lesion appears to be confined to a cystic structure.

See also

References

  1. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid10881733
  2. ↑ 2.0 2.1 2.2 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 399. ISBN 978-0443069208.
  3. ↑ Burkholz, KJ.; Wood, BP.; Zuppan, C.. "Best cases from the AFIP: Borderline papillary serous tumor of the right ovary.". Radiographics 25 (6): 1689-92. doi:10.1148/rg.256055015. PMID 16284143.
  4. ↑ Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.
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