Difference between revisions of "Desquamative interstitial pneumonia"
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==General== | ==General== | ||
* | *Rare.<ref name=pmid20854463/> | ||
*Strong association with smoking.<ref name=Ref_WMSP93>{{Ref WMSP|93}}</ref><ref name=pmid26324804>{{Cite journal | last1 = Margaritopoulos | first1 = GA. | last2 = Vasarmidi | first2 = E. | last3 = Jacob | first3 = J. | last4 = Wells | first4 = AU. | last5 = Antoniou | first5 = KM. | title = Smoking and interstitial lung diseases. | journal = Eur Respir Rev | volume = 24 | issue = 137 | pages = 428-35 | month = Sep | year = 2015 | doi = 10.1183/16000617.0050-2015 | PMID = 26324804 }}</ref> | *Strong association with smoking.<ref name=Ref_WMSP93>{{Ref WMSP|93}}</ref><ref name=pmid26324804>{{Cite journal | last1 = Margaritopoulos | first1 = GA. | last2 = Vasarmidi | first2 = E. | last3 = Jacob | first3 = J. | last4 = Wells | first4 = AU. | last5 = Antoniou | first5 = KM. | title = Smoking and interstitial lung diseases. | journal = Eur Respir Rev | volume = 24 | issue = 137 | pages = 428-35 | month = Sep | year = 2015 | doi = 10.1183/16000617.0050-2015 | PMID = 26324804 }}</ref> | ||
**Thought to be advanced ''[[RBILD]]''. | **Thought to be advanced ''[[RBILD]]''. | ||
*May be seen in non-smokers (up to ~40% of cases) due to occupational exposures, drugs, viral illnesses and autoimmune diseases.<ref name=pmid23728865>{{Cite journal | last1 = Godbert | first1 = B. | last2 = Wissler | first2 = MP. | last3 = Vignaud | first3 = JM. | title = Desquamative interstitial pneumonia: an analytic review with an emphasis on aetiology. | journal = Eur Respir Rev | volume = 22 | issue = 128 | pages = 117-23 | month = Jun | year = 2013 | doi = 10.1183/09059180.00005812 | PMID = 23728865 }}</ref> | *May be seen in non-smokers (up to ~40% of cases) due to occupational exposures, drugs, viral illnesses and autoimmune diseases.<ref name=pmid23728865>{{Cite journal | last1 = Godbert | first1 = B. | last2 = Wissler | first2 = MP. | last3 = Vignaud | first3 = JM. | title = Desquamative interstitial pneumonia: an analytic review with an emphasis on aetiology. | journal = Eur Respir Rev | volume = 22 | issue = 128 | pages = 117-23 | month = Jun | year = 2013 | doi = 10.1183/09059180.00005812 | PMID = 23728865 }}</ref> | ||
Revision as of 04:30, 21 March 2016
| Desquamative interstitial pneumonia | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | abundant brown pigmented airspace macrophages (smoker's macrophages), architecture preserved ("linear fibrosis") |
| LM DDx | amiodarone toxicity, fibrotic NSIP, RBILD |
| Site | lung - see diffuse lung diseases |
|
| |
| Associated Dx | +/-smoking |
| Prevalence | uncommon |
| Treatment | stop smoking/remove insult |
Desquamative interstitial pneumonia, abbreviated DIP, is a diffuse lung disease that is strongly associated with smoking.
General
- Rare.[1]
- Strong association with smoking.[2][3]
- Thought to be advanced RBILD.
- May be seen in non-smokers (up to ~40% of cases) due to occupational exposures, drugs, viral illnesses and autoimmune diseases.[4]
Diagnosis:
- Requires - surgical biopsy.[4]
Treatment:
- Stop smoking/remove or manage underlying cause.
Microscopic
Features:[1]
- Abundant airspace macrophages - usually with brown pigment (so called smoker's macrophages) - key feature.
- Interstitial inflammation or interstitial fibrosis with a preserved architecture - so called "linear fibrosis".
Notes:
- Some fields of view may be indistinguishable from RBILD.
DDx:
Images
Stains
- Macrophages PAS +ve.
See also
References
- ↑ 1.0 1.1 Tazelaar, HD.; Wright, JL.; Churg, A. (Mar 2011). "Desquamative interstitial pneumonia.". Histopathology 58 (4): 509-16. doi:10.1111/j.1365-2559.2010.03649.x. PMID 20854463.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 93. ISBN 978-0781765275.
- ↑ Margaritopoulos, GA.; Vasarmidi, E.; Jacob, J.; Wells, AU.; Antoniou, KM. (Sep 2015). "Smoking and interstitial lung diseases.". Eur Respir Rev 24 (137): 428-35. doi:10.1183/16000617.0050-2015. PMID 26324804.
- ↑ 4.0 4.1 Godbert, B.; Wissler, MP.; Vignaud, JM. (Jun 2013). "Desquamative interstitial pneumonia: an analytic review with an emphasis on aetiology.". Eur Respir Rev 22 (128): 117-23. doi:10.1183/09059180.00005812. PMID 23728865.