Difference between revisions of "Pulmonary Langerhans cell histiocytosis"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Pulmonary Langerhans cell histiocytosis -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Langerhans cell histiocytosis of the lung. [[H&E stain]]. | ||
| Synonyms = eosinophilic granuloma (of the lung) | | Synonyms = eosinophilic granuloma (of the lung) | ||
| Micro = | | Micro = cellular peribronchiolar nodules with Langerhans cells (pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance), +/-smoker's macrophages (brown pigmented airspace macrophages), +/-eosinophilia (typical - may be rare) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = Langerhans cells (CD1a +ve, S-100 +ve, CD207 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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==IHC== | ==IHC== | ||
Langerhans cells: | |||
*S100 +ve.<ref name=Ref_PPP237>{{Ref PPP|237}}</ref> | |||
*CD1a +ve.<ref name=Ref_PPP237>{{Ref PPP|237}}</ref> | |||
*CD207 (AKA Langerin) +ve | |||
==See also== | ==See also== | ||
Revision as of 06:20, 23 December 2015
| Pulmonary Langerhans cell histiocytosis | |
|---|---|
| Diagnosis in short | |
 Langerhans cell histiocytosis of the lung. H&E stain. | |
|
| |
| Synonyms | eosinophilic granuloma (of the lung) |
|
| |
| LM | cellular peribronchiolar nodules with Langerhans cells (pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance), +/-smoker's macrophages (brown pigmented airspace macrophages), +/-eosinophilia (typical - may be rare) |
| IHC | Langerhans cells (CD1a +ve, S-100 +ve, CD207 +ve |
| Site | lung - see medical lung diseases |
|
| |
| Prevalence | uncommon |
| Radiology | upper lung zones |
| Prognosis | good with smoking cessation |
Pulmonary Langerhans cell histiocytosis is an uncommon smoking-related lung disease.
It is also known as eosinophilic granuloma of the lung.
General
- Associated with smoking.[1]
- Not associated with systemic diseases of Langerhans cells (AKA Hand-Schueller-Christian disease).
Subtypes:[1]
- Cellular form.
- Fibrotic form.
One form usually predominates.
Radiology
- Upper lung zones.
Microscopic
Features:[2]
- Cellular peribronchiolar nodules with:
- Langerhans cells - key feature:
- Pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance.
- +/-Smoker's macrophages (brown pigmented airspace macrophages).
- +/-Eosinophilia (may be rare) - significantly narrow DDx.
- Chronic inflammatory cells (lymphocytes). (???)
- Langerhans cells - key feature:
Images:
IHC
Langerhans cells:
See also
References
- ↑ 1.0 1.1 Leslie, Kevin O.; Wick, Mark R. (2004). Practical Pulmonary Pathology: A Diagnostic Approach (1st ed.). Churchill Livingstone. pp. 234. ISBN 978-0443066313.
- ↑ 2.0 2.1 2.2 Leslie, Kevin O.; Wick, Mark R. (2004). Practical Pulmonary Pathology: A Diagnostic Approach (1st ed.). Churchill Livingstone. pp. 237. ISBN 978-0443066313.