Difference between revisions of "Pulmonary Langerhans cell histiocytosis"
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'''Pulmonary Langerhans cell histiocytosis''' is an uncommon [[smoking|smoking-related lung disease]]. | |||
It is also known as '''eosinophilic granuloma of the lung'''. | |||
==General== | |||
*Associated with smoking.<ref name=Ref_PPP234>{{Ref PPP|234}}</ref> | |||
*Not associated with systemic diseases of Langerhans cells ([[AKA]] [[Langerhans cell histiocytosis|Hand-Schueller-Christian disease]]). | |||
Subtypes:<ref name=Ref_PPP234/> | |||
*Cellular form. | |||
*Fibrotic form. | |||
One form usually predominates. | |||
===Radiology== | |||
*Upper lung zones. | |||
==Microscopic== | |||
Features:<ref name=Ref_PPP237>{{Ref PPP|237}}</ref> | |||
*Cellular peribronchiolar nodules with: | |||
**Langerhans cells - '''key feature''': | |||
***Pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance. | |||
**+/-Smoker's macrophages (brown pigmented airspace macrophages). | |||
**+/-Eosinophilia (may be rare) - '''significantly narrow DDx'''. | |||
**Chronic inflammatory cells (lymphocytes). (???) | |||
Images: | |||
*[http://path.upmc.edu/cases/case299.html Pulmonary LCH & adenocarcinoma - several images (upmc.edu)]. | |||
==IHC== | |||
*Langerhans cells: S100+ and CD1a+.<ref name=Ref_PPP237>{{Ref PPP|237}}</ref> | |||
==See also== | |||
*[[Medical lung diseases]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Medical lung diseases]] | |||
Revision as of 06:06, 23 December 2015
Pulmonary Langerhans cell histiocytosis is an uncommon smoking-related lung disease.
It is also known as eosinophilic granuloma of the lung.
General
- Associated with smoking.[1]
- Not associated with systemic diseases of Langerhans cells (AKA Hand-Schueller-Christian disease).
Subtypes:[1]
- Cellular form.
- Fibrotic form.
One form usually predominates.
=Radiology
- Upper lung zones.
Microscopic
Features:[2]
- Cellular peribronchiolar nodules with:
- Langerhans cells - key feature:
- Pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance.
- +/-Smoker's macrophages (brown pigmented airspace macrophages).
- +/-Eosinophilia (may be rare) - significantly narrow DDx.
- Chronic inflammatory cells (lymphocytes). (???)
- Langerhans cells - key feature:
Images:
IHC
- Langerhans cells: S100+ and CD1a+.[2]
See also
References
- ↑ 1.0 1.1 Leslie, Kevin O.; Wick, Mark R. (2004). Practical Pulmonary Pathology: A Diagnostic Approach (1st ed.). Churchill Livingstone. pp. 234. ISBN 978-0443066313.
- ↑ 2.0 2.1 Leslie, Kevin O.; Wick, Mark R. (2004). Practical Pulmonary Pathology: A Diagnostic Approach (1st ed.). Churchill Livingstone. pp. 237. ISBN 978-0443066313.