Difference between revisions of "Renal oncocytosis"
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*Rare. | *Rare. | ||
*May be seen in the context of [[Birt–Hogg–Dubé syndrome]] or [[chronic renal failure]] or may be sporadic.<ref name=pmid23018240/> | *May be seen in the context of [[Birt–Hogg–Dubé syndrome]] or [[chronic renal failure]] or may be sporadic.<ref name=pmid23018240/> | ||
**Chronic renal failure seen in 50% of cases in one series.<ref name=pmid21239013>{{Cite journal | last1 = Adamy | first1 = A. | last2 = Lowrance | first2 = WT. | last3 = Yee | first3 = DS. | last4 = Chong | first4 = KT. | last5 = Bernstein | first5 = M. | last6 = Tickoo | first6 = SK. | last7 = Coleman | first7 = JA. | last8 = Russo | first8 = P. | title = Renal oncocytosis: management and clinical outcomes. | journal = J Urol | volume = 185 | issue = 3 | pages = 795-801 | month = Mar | year = 2011 | doi = 10.1016/j.juro.2010.10.068 | PMID = 21239013 }}</ref> | |||
==Gross== | ==Gross== | ||
Revision as of 04:08, 4 December 2015
| Renal oncocytosis | |
|---|---|
| Diagnosis in short | |
| LM DDx | other renal tumours with eosinophilic cytoplasm |
| IHC | characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour |
| Gross | multiple brown kidney nodules (bilateral or unilateral) |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney - see kidney tumours |
|
| |
| Syndromes | Birt–Hogg–Dubé syndrome |
|
| |
| Clinical history | +/-chronic renal failure and hemodialysis |
| Prevalence | rare |
| Radiology | multiple renal tumours |
| Clin. DDx | metastatic disease, multifocal renal cell carcinoma |
Renal oncocytosis is the presence of multiple oncocytic lesions within the kidney.[1]
General
- Rare.
- May be seen in the context of Birt–Hogg–Dubé syndrome or chronic renal failure or may be sporadic.[1]
- Chronic renal failure seen in 50% of cases in one series.[2]
Gross
- Multiple (unilateral or bilateral) brown-coloured nodules.[1]
Microscopic
Features:
- Any mixture of oncocytic tumours (hybrid tumour, chromophobe renal cell carcinoma, renal oncocytoma).
DDx:
- Hybrid tumour.
- Chromophobe renal cell carcinoma.
- Renal oncocytoma.
- Other renal tumours with eosinophilic cytoplasm.
IHC
- Characteristic of the histologic appearance.[1]
- Stain like renal oncocytomas, chromophobe renal cell carcinomas and hybrid tumours.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Kuroda, N.; Tanaka, A.; Ohe, C.; Mikami, S.; Nagashima, Y.; Sasaki, T.; Inoue, K.; Hes, O. et al. (Nov 2012). "Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.". Histol Histopathol 27 (11): 1407-12. PMID 23018240.
- ↑ Adamy, A.; Lowrance, WT.; Yee, DS.; Chong, KT.; Bernstein, M.; Tickoo, SK.; Coleman, JA.; Russo, P. (Mar 2011). "Renal oncocytosis: management and clinical outcomes.". J Urol 185 (3): 795-801. doi:10.1016/j.juro.2010.10.068. PMID 21239013.