Difference between revisions of "Adenosis of the prostate gland"
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Glandular crowding. | *Glandular crowding - '''key feature'''. | ||
**Glands may be back-to-back. | **Glands may be back-to-back. | ||
*Lack of prominent [[nucleoli]]. | *Lack of prominent [[nucleoli]]. | ||
Revision as of 21:30, 8 June 2015
Adenosis of the prostate gland, also adenosis of the prostate, is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) prostatic adenocarcinoma.[1]
It is also known as atypical adenomatous hyperplasia.[2][3]
General
- May be mistaken for prostatic adenocarcinoma.[4]
- Lesion of the transistion zone of the prostate.[1]
Microscopic
Features:
- Glandular crowding - key feature.
- Glands may be back-to-back.
- Lack of prominent nucleoli.
DDx:
- Adenocarcinoma of the prostate.
- Foamy gland adenocarcinoma - typically has intraluminal crystalloids.
- Bulbourethral gland - at apex of prostate.
IHC
- CK5/6 +ve. ‡
- p63 +ve. ‡
- AMACR -ve.
Notes:
- ‡ Often patchy - some glands in a group may lack basal cells.
See also
References
- ↑ 1.0 1.1 Gaudin, PB.; Epstein, JI. (Jul 1995). "Adenosis of the prostate. Histologic features in needle biopsy specimens.". Am J Surg Pathol 19 (7): 737-47. PMID 7793471.
- ↑ Molinié, V.; Vadrot, J.; Duchatelle, V.; Balaton, A.; Abbey-Tobby, A.; Baumert, H. (Apr 2012). "[Diagnostic issues of prostate biopsies. Case 2. Atypical adenomatous hyperplasia (adenosis)].". Ann Pathol 32 (2): 114-7. doi:10.1016/j.annpat.2012.02.003. PMID 22520603.
- ↑ Humphrey, PA. (Dec 2012). "Atypical adenomatous hyperplasia (adenosis) of the prostate.". J Urol 188 (6): 2371-2. doi:10.1016/j.juro.2012.09.058. PMID 23000851.
- ↑ Epstein, JI. (Jan 2012). "Diagnosis of limited adenocarcinoma of the prostate.". Histopathology 60 (1): 28-40. doi:10.1111/j.1365-2559.2011.03990.x. PMID 22212076.