Difference between revisions of "Adenoid cystic carcinoma of the breast"

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#redirect [[Invasive breast cancer#Adenoid cystic carcinoma of the breast]]
'''Adenoid cystic carcinoma of the breast''' is a rare type of [[breast cancer]] that is similar to a relatively common tumour of the [[salivary gland]].
 
==General==
*Like tumour of the [[salivary gland]].
*Very rare <0.1% of breast malignancies.<ref name=pmid22154460/>
*Good prognosis.<ref name=pmid22154460>{{Cite journal  | last1 = Boujelbene | first1 = N. | last2 = Khabir | first2 = A. | last3 = Boujelbene | first3 = N. | last4 = Jeanneret Sozzi | first4 = W. | last5 = Mirimanoff | first5 = RO. | last6 = Khanfir | first6 = K. | title = Clinical review - Breast adenoid cystic carcinoma. | journal = Breast | volume =  | issue =  | pages =  | month = Dec | year = 2011 | doi = 10.1016/j.breast.2011.11.006 | PMID = 22154460 }}</ref>
 
==Microscopic==
:See: ''[[Adenoid cystic carcinoma]]'' article.
 
==IHC==
*One of the 'good prognosis' triple negative breast cancers - ER, PR and HER2 negative<ref>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref>
*Basal-like breast cancer - p63 and CK5/6 positive<ref>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref>
CD117 positive<ref>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref>
 
DDx:
*Cribriform [[DCIS]].
*Invasive cribriform carcinoma.
*[[Collagenous spherulosis]].
 
==Images==
*[http://path.upmc.edu/cases/case140.html Adenoid cystic carcinoma of the breast (upmc.edu)].>>
<gallery>
Image:Breast AdenoidCysticCarcinoma 2 LP CTR.jpg|Breast Adenoid Cystic Carcinoma - low power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP CTR (3).jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP2 CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP2 CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma MP CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma MP CTR (2).jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP CTR (2).jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP CTR.jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP3 CTR.jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP2 CTR.jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType LP 14BR***.jpg|Breast - Adenoid Cystic Carcinoma -  Solid Type - Low power (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType 14BR***.jpg|Breast - Adenoid Cystic Carcinoma -  Solid Type - medium power - Aggregates of basaloid cells without tubule or cyst formation.  (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType HP 14BR***.jpg|Breast - Adenoid Cystic Carcinoma -  Solid Type - High power (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType 2 14BR***.jpg|Breast Adenoid Cystic Carcinoma - Solid Type - high power (SKB)
</gallery>
 
==Other Resources==
Pathology Outlines [http://www.pathologyoutlines.com/topic/breastmalignantadenoidcystic.html]
 
==See also==
*[[Invasive breast carcinoma]].
*[[Adenoid cystic carcinoma]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Breast pathology]]

Revision as of 07:56, 14 April 2015

Adenoid cystic carcinoma of the breast is a rare type of breast cancer that is similar to a relatively common tumour of the salivary gland.

General

Microscopic

See: Adenoid cystic carcinoma article.

IHC

  • One of the 'good prognosis' triple negative breast cancers - ER, PR and HER2 negative[2]
  • Basal-like breast cancer - p63 and CK5/6 positive[3]

CD117 positive[4]

DDx:

Images

  • Breast Adenoid Cystic Carcinoma - low power (SKB)

  • Breast Adenoid Cystic Carcinoma - medium power (SKB)

  • Breast Adenoid Cystic Carcinoma - medium power (SKB)

  • Breast Adenoid Cystic Carcinoma - medium power (SKB)

  • Breast Adenoid Cystic Carcinoma - medium power (SKB)

  • Breast Adenoid Cystic Carcinoma - medium power (SKB)

  • Breast Adenoid Cystic Carcinoma - medium power (SKB)

  • Breast Adenoid Cystic Carcinoma - high power (SKB)

  • Breast Adenoid Cystic Carcinoma - high power (SKB)

  • Breast Adenoid Cystic Carcinoma - high power (SKB)

  • Breast Adenoid Cystic Carcinoma - high power (SKB)

  • Breast - Adenoid Cystic Carcinoma - Solid Type - Low power (SKB)

  • Breast - Adenoid Cystic Carcinoma - Solid Type - medium power - Aggregates of basaloid cells without tubule or cyst formation. (SKB)

  • Breast - Adenoid Cystic Carcinoma - Solid Type - High power (SKB)

  • Breast Adenoid Cystic Carcinoma - Solid Type - high power (SKB)

Other Resources

Pathology Outlines [1]

See also

References

  1. ↑ 1.0 1.1 Boujelbene, N.; Khabir, A.; Boujelbene, N.; Jeanneret Sozzi, W.; Mirimanoff, RO.; Khanfir, K. (Dec 2011). "Clinical review - Breast adenoid cystic carcinoma.". Breast. doi:10.1016/j.breast.2011.11.006. PMID 22154460.
  2. ↑ Azoulay, S.; Laé, M.; Fréneaux, P.; Merle, S.; Al Ghuzlan, A.; Chnecker, C.; Rosty, C.; Klijanienko, J. et al. (Dec 2005). "KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome.". Mod Pathol 18 (12): 1623-31. doi:10.1038/modpathol.3800483. PMID 16258515.
  3. ↑ Azoulay, S.; Laé, M.; Fréneaux, P.; Merle, S.; Al Ghuzlan, A.; Chnecker, C.; Rosty, C.; Klijanienko, J. et al. (Dec 2005). "KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome.". Mod Pathol 18 (12): 1623-31. doi:10.1038/modpathol.3800483. PMID 16258515.
  4. ↑ Azoulay, S.; Laé, M.; Fréneaux, P.; Merle, S.; Al Ghuzlan, A.; Chnecker, C.; Rosty, C.; Klijanienko, J. et al. (Dec 2005). "KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome.". Mod Pathol 18 (12): 1623-31. doi:10.1038/modpathol.3800483. PMID 16258515.
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