Difference between revisions of "Apocrine carcinoma of the breast"

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*[http://path.upmc.edu/cases/case209/micro.html Apocrine carcinoma (upmc.edu)].
*[http://path.upmc.edu/cases/case209/micro.html Apocrine carcinoma (upmc.edu)].
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Image:Breast ApocrineCarcinoma LP2 CTR.jpg|Breast - Apocrine Carcinoma - Low power (SKB)
Image:Breast ApocrineCarcinoma PerienuralInvasion MP CTR.jpg|Breast - Apocrine Carcinoma - Perineural invasion - High power (SKB)
Image:Breast ApocrineCarcinoma LP CTR.jpg|Breast - Apocrine Carcinoma - Low power (SKB)
Image:Breast ApocrineCarcinoma LP CTR.jpg|Breast - Apocrine Carcinoma - Low power (SKB)
Image:Breast ApocrineCarcinoma LP2 CTR.jpg|Breast - Apocrine Carcinoma - Low power (SKB)
Image:Breast ApocrineCarcinoma MP2 CTR.jpg|Breast - Apocrine Carcinoma - Medium power (SKB)
Image:Breast ApocrineCarcinoma MP2 CTR.jpg|Breast - Apocrine Carcinoma - Medium power (SKB)
Image:Breast ApocrineCarcinoma PerienuralInvasion MP CTR.jpg|Breast - Apocrine Carcinoma - Perineural invasion - High power (SKB)
Image:Breast ApocrineCarcinoma HP CTR.jpg|Breast - Apocrine Carcinoma - High power (SKB)
Image:Breast ApocrineCarcinoma HP CTR.jpg|Breast - Apocrine Carcinoma - High power (SKB)
Image:Breast ApocrineCarcinoma HP2 CTR.jpg|Breast - Apocrine Carcinoma - High power (SKB)
Image:Breast ApocrineCarcinoma HP2 CTR.jpg|Breast - Apocrine Carcinoma - High power (SKB)

Revision as of 11:11, 1 April 2015

Apocrine carcinoma of the breast
Diagnosis in short
LM apocrine morphology (cells with prominent nucleoli - may be multiple, abundant granular eosinophilic cytoplasm) - must be >=90% of tumour, loss of basal cells
LM DDx glycogen-rich clear cell carcinoma of the breast
IHC AR +ve, GCDFP-15 +ve, ER -ve, PR -ve
Site breast - see invasive breast cancer
Prevalence uncommon

Apocrine carcinoma of the breast is a rare form of invasive breast cancer.

General

  • Need >=90% apocrine morphology.[1]

Microscopic

Features:[1]

  • Prominent nucleoli.
    • Often multiple.[2]
  • Abundant granular eosinophilic cytoplasm.
  • Architecture like invasive ductal carcinomas no special type.

DDx:

Images

www:

  • Breast - Apocrine Carcinoma - Low power (SKB)

  • Breast - Apocrine Carcinoma - Perineural invasion - High power (SKB)

  • Breast - Apocrine Carcinoma - Low power (SKB)

  • Breast - Apocrine Carcinoma - Medium power (SKB)

  • Breast - Apocrine Carcinoma - High power (SKB)

  • Breast - Apocrine Carcinoma - High power (SKB)

IHC

Smaller tumours classically:[3]

Usually:[1]

  • ER -ve.
  • PR -ve.

See also

References

  1. ↑ 1.0 1.1 1.2 O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066801.
  2. ↑ O'Malley, FP.; Bane, A. (Jan 2008). "An update on apocrine lesions of the breast.". Histopathology 52 (1): 3-10. doi:10.1111/j.1365-2559.2007.02888.x. PMID 18171412.
  3. ↑ Honma, N.; Takubo, K.; Akiyama, F.; Sawabe, M.; Arai, T.; Younes, M.; Kasumi, F.; Sakamoto, G. (Aug 2005). "Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.". Histopathology 47 (2): 195-201. doi:10.1111/j.1365-2559.2005.02181.x. PMID 16045781.
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