Difference between revisions of "Poorly differentiated thyroid carcinoma"

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'''Poorly differentiated thyroid carcinoma''', abbreviated '''PDTC''', is a distinct type of thyroid carcinoma recognized in the 2004 WHO classification of thyroid tumours.<ref name=pmid21969055>{{Cite journal  | last1 = Tallini | first1 = G. | title = Poorly differentiated thyroid carcinoma. Are we there yet? | journal = Endocr Pathol | volume = 22 | issue = 4 | pages = 190-4 | month = Dec | year = 2011 | doi = 10.1007/s12022-011-9176-5 | PMID = 21969055 }}</ref><ref name=pmid19960273>{{Cite journal  | last1 = Volante | first1 = M. | last2 = Papotti | first2 = M. | title = Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours. | journal = Endocr Pathol | volume = 21 | issue = 1 | pages = 1-6 | month = Mar | year = 2010 | doi = 10.1007/s12022-009-9100-4 | PMID = 19960273 }}</ref>
'''Poorly differentiated thyroid carcinoma''', abbreviated '''PDTC''', is a distinct type of thyroid carcinoma that is recognized in the 2004 WHO classification of thyroid tumours.<ref name=pmid21969055>{{Cite journal  | last1 = Tallini | first1 = G. | title = Poorly differentiated thyroid carcinoma. Are we there yet? | journal = Endocr Pathol | volume = 22 | issue = 4 | pages = 190-4 | month = Dec | year = 2011 | doi = 10.1007/s12022-011-9176-5 | PMID = 21969055 }}</ref><ref name=pmid19960273>{{Cite journal  | last1 = Volante | first1 = M. | last2 = Papotti | first2 = M. | title = Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours. | journal = Endocr Pathol | volume = 21 | issue = 1 | pages = 1-6 | month = Mar | year = 2010 | doi = 10.1007/s12022-009-9100-4 | PMID = 19960273 }}</ref> It does not refer to high grade thyroid tumours.<ref name=pmid21969055/>


It does not refer to high grade thyroid tumour.<ref name=pmid21969055/>
==General==
*Prognosis between that of [[papillary thyroid carcinoma]] and [[anaplastic thyroid carcinoma]].<ref name=pmid20562850>{{Cite journal  | last1 = Asioli | first1 = S. | last2 = Erickson | first2 = LA. | last3 = Righi | first3 = A. | last4 = Jin | first4 = L. | last5 = Volante | first5 = M. | last6 = Jenkins | first6 = S. | last7 = Papotti | first7 = M. | last8 = Bussolati | first8 = G. | last9 = Lloyd | first9 = RV. | title = Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression. | journal = Mod Pathol | volume = 23 | issue = 9 | pages = 1269-78 | month = Sep | year = 2010 | doi = 10.1038/modpathol.2010.117 | PMID = 20562850 }}</ref>
 
==Microscopic==
Required features - so called ''Turin criteria'':<ref name=pmid17667551>{{Cite journal  | last1 = Volante | first1 = M. | last2 = Collini | first2 = P. | last3 = Nikiforov | first3 = YE. | last4 = Sakamoto | first4 = A. | last5 = Kakudo | first5 = K. | last6 = Katoh | first6 = R. | last7 = Lloyd | first7 = RV. | last8 = LiVolsi | first8 = VA. | last9 = Papotti | first9 = M. | title = Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. | journal = Am J Surg Pathol | volume = 31 | issue = 8 | pages = 1256-64 | month = Aug | year = 2007 | doi = 10.1097/PAS.0b013e3180309e6a | PMID = 17667551 }}</ref>
# Solid, trabecular or insular pattern of growth.
# Absence of nuclear features for (conventional) [[papillary thyroid carcinoma]].
# One of the following:
## Convoluted nuclei.
## >= 3 mitoses/10 [[HPF]].
## Tumour necrosis.


==See also==
==See also==
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[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Thyroid gland]]

Latest revision as of 03:02, 4 March 2015

Poorly differentiated thyroid carcinoma, abbreviated PDTC, is a distinct type of thyroid carcinoma that is recognized in the 2004 WHO classification of thyroid tumours.[1][2] It does not refer to high grade thyroid tumours.[1]

General

Microscopic

Required features - so called Turin criteria:[4]

  1. Solid, trabecular or insular pattern of growth.
  2. Absence of nuclear features for (conventional) papillary thyroid carcinoma.
  3. One of the following:
    1. Convoluted nuclei.
    2. >= 3 mitoses/10 HPF.
    3. Tumour necrosis.

See also

References

  1. ↑ 1.0 1.1 Tallini, G. (Dec 2011). "Poorly differentiated thyroid carcinoma. Are we there yet?". Endocr Pathol 22 (4): 190-4. doi:10.1007/s12022-011-9176-5. PMID 21969055.
  2. ↑ Volante, M.; Papotti, M. (Mar 2010). "Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours.". Endocr Pathol 21 (1): 1-6. doi:10.1007/s12022-009-9100-4. PMID 19960273.
  3. ↑ Asioli, S.; Erickson, LA.; Righi, A.; Jin, L.; Volante, M.; Jenkins, S.; Papotti, M.; Bussolati, G. et al. (Sep 2010). "Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression.". Mod Pathol 23 (9): 1269-78. doi:10.1038/modpathol.2010.117. PMID 20562850.
  4. ↑ Volante, M.; Collini, P.; Nikiforov, YE.; Sakamoto, A.; Kakudo, K.; Katoh, R.; Lloyd, RV.; LiVolsi, VA. et al. (Aug 2007). "Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach.". Am J Surg Pathol 31 (8): 1256-64. doi:10.1097/PAS.0b013e3180309e6a. PMID 17667551.
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