Difference between revisions of "Lung metastasis"

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[[Image:Ewing sarcoma - intermed mag.jpg|thumb|right|250px|Lung metastasis ([[Ewing sarcoma]]). [[H&E stain]].]]
'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.
'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.


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*Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]].
*Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]].
*Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]].
*Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]].
===Images===
<gallery>
Image:Ewing sarcoma - intermed mag.jpg | Lung metastasis ([[Ewing sarcoma|ES]]) - intermed. mag.
Image:Ewing sarcoma - high mag.jpg | Lung metastasis (ES) - high mag.
Image:Ewing sarcoma - very high mag.jpg | Lung metastasis (ES) - very high mag.
</gallery>


==IHC==
==IHC==

Revision as of 05:37, 29 October 2014

Lung metastasis (Ewing sarcoma). H&E stain.

Lung metastasis, also pulmonary metastasis and metastatic lung disease, is relatively common and generally carries a poor prognosis.

General

  • Relatively common.

Microscopic

Features:

  • Variable - dependent on site of origin.

Colorectal adenocarcinoma - usually distinctive morphologically:

  • Typically gland forming.
    • Ellipsoid/elongated pseudostratified nuclei with moderate nuclear atypia.
    • +/-Dirty necrosis.

Others:

Images

IHC

  • TTF-1 -ve/+ve.
  • CK20 +ve/-ve.
    • Positive in colorectal carcinoma - very useful.
    • Negative in lung primaries.
  • GATA3 +ve/-ve.
  • CK7 -ve/+ve.
    • Positive in lung adenocarcinoma and small carcinoma of the lung.
    • Positive in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, salivary gland.
    • Negative in poorly differentiated carcinoma of the lung and squamous carcinoma of the lung.

See also

References

  1. Chang, A.; Amin, A.; Gabrielson, E.; Illei, P.; Roden, RB.; Sharma, R.; Epstein, JI. (Oct 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung.". Am J Surg Pathol 36 (10): 1472-6. doi:10.1097/PAS.0b013e318260cde7. PMID 22982890.