Difference between revisions of "Renal angiomyoadenomatous tumour"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = leiomyomatous capsule of variable thickness, tubular structures with (1) apical snouts, and (2) clear cells with basal nuclei and mild [[nuclear atypia]]
| Subtypes  =
| LMDDx      = [[clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]], (epithelioid) [[angiomyolipoma]], [[mixed epithelial and stromal tumour of the kidney|mixed epithelial and stromal tumour]]
| Stains    =
| IHC        = CK7 +ve, CK20 +ve, CAM5.2 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      = tan-brown mass +/-cystic component
| Grossing  =
| Site      = [[kidney]] - see ''[[kidney tumours]]''
| Assdx      = possibly related to [[clear cell papillary renal cell carcinoma]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = extremely very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Renal angiomyoadenomatous tumour''', abbreviated '''RAT''', is an uncommon [[kidney tumour]] not recognized by the [[WHO]] classification of renal neoplasia or the Vancouver modification.
'''Renal angiomyoadenomatous tumour''', abbreviated '''RAT''', is an uncommon [[kidney tumour]] not recognized by the [[WHO]] classification of renal neoplasia or the Vancouver modification.



Revision as of 05:07, 21 October 2014

Renal angiomyoadenomatous tumour
Diagnosis in short

LM leiomyomatous capsule of variable thickness, tubular structures with (1) apical snouts, and (2) clear cells with basal nuclei and mild nuclear atypia
LM DDx clear cell renal cell carcinoma, papillary renal cell carcinoma, (epithelioid) angiomyolipoma, mixed epithelial and stromal tumour
IHC CK7 +ve, CK20 +ve, CAM5.2 +ve
Gross tan-brown mass +/-cystic component
Site kidney - see kidney tumours

Associated Dx possibly related to clear cell papillary renal cell carcinoma
Prevalence extremely very rare
Prognosis good

Renal angiomyoadenomatous tumour, abbreviated RAT, is an uncommon kidney tumour not recognized by the WHO classification of renal neoplasia or the Vancouver modification.

General

Clincal:

  • Typical age (years): 50s.[2]
    • Age range: 40-93 years.

Gross

Features:[2]

  • Tan-brown renal mass +/-cystic component.

Microscopic

Features:[2][3]

  • Leiomyomatous capsule of variable thickness - key feature.
  • Tubular structures with:

DDx:[2][4]

IHC

Features:[3]

  • CK7 +ve.
  • CK20 +ve.
  • CAM5.2 +ve.
  • AE1/AE3 +ve.

See also

References

  1. Petersson, F.; Grossmann, P.; Hora, M.; Sperga, M.; Montiel, DP.; Martinek, P.; Gutierrez, ME.; Bulimbasic, S. et al. (Jul 2013). "Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma.". Hum Pathol 44 (7): 1412-20. doi:10.1016/j.humpath.2012.11.019. PMID 23434146.
  2. 2.0 2.1 2.2 2.3 Singh, C.; Kendi, AT.; Manivel, JC.; Pambuccian, SE. (Dec 2012). "Renal angiomyoadenomatous tumor.". Ann Diagn Pathol 16 (6): 470-6. doi:10.1016/j.anndiagpath.2012.01.006. PMID 22534244.
  3. 3.0 3.1 Michal, M.; Hes, O.; Nemcova, J.; Sima, R.; Kuroda, N.; Bulimbasic, S.; Franco, M.; Sakaida, N. et al. (Jan 2009). "Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity.". Virchows Arch 454 (1): 89-99. doi:10.1007/s00428-008-0697-3. PMID 19020896.
  4. Petersson, F.; Branzovsky, J.; Martinek, P.; Korabecna, M.; Kruslin, B.; Hora, M.; Peckova, K.; Bauleth, K. et al. (Jul 2014). "The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process.". Virchows Arch 465 (1): 89-96. doi:10.1007/s00428-014-1591-9. PMID 24838683.