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Difference between revisions of "Dermatologic neoplasms"
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==Melanoma== | ==Melanoma== | ||
===General=== | |||
*[[AKA]] ''Malignant melanoma''. | *[[AKA]] ''Malignant melanoma''. | ||
*Main DDx: [[melanocytic lesions]] - especially if pigmented. | *Main DDx: [[melanocytic lesions]] - especially if pigmented. | ||
*Known as the great mimicker in pathology; it may look like many things. | *Known as the great mimicker in pathology; it may look like many things. | ||
===Clinical=== | ====Clinical==== | ||
*''ABCD'' = asymmetric, borders (irregular), colour (black), diameter (large). | *''ABCD'' = asymmetric, borders (irregular), colour (black), diameter (large). | ||
=== | ===Microscopic=== | ||
Features: | |||
*Classic appearance of melanoma: | *Classic appearance of melanoma: | ||
**Loosely cohesive; mix of small nests of cells, single cells. | **Loosely cohesive; mix of small nests of cells, single cells. | ||
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*''Fontana-Masson stain'', stains melanin.<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | *''Fontana-Masson stain'', stains melanin.<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | ||
**May be useful to differentiate melanin from other brown stuff (e.g. lipofuscin, hemosiderin). | **May be useful to differentiate melanin from other brown stuff (e.g. lipofuscin, hemosiderin). | ||
*SOX10 +ve -- useful for diff. from excision scar.<ref name=pmid20653825>{{cite journal |author=Ramos-Herberth FI, Karamchandani J, Kim J, Dadras SS |title=SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar |journal=J. Cutan. Pathol. |volume=37 |issue=9 |pages=944–52 |year=2010 |month=September |pmid=20653825 |doi=10.1111/j.1600-0560.2010.01568.x |url=}}</ref> | |||
===Electron microscopy=== | ===Electron microscopy=== | ||