Difference between revisions of "Metaphyseal fibrous defect"

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==Relevant Diagnostic Groups==
==Relevant Diagnostic Groups==
*Clinical
*Clinical
**FOG MACHINES - acronym for radiographically lytic bone lesions <ref> {{http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic}} </ref>
**FOG MACHINES - acronym for radiographically lytic bone lesions <ref>URL: [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]. Accessed on: October 14, 2014.</ref>
**'Skeletal do not touch list' <ref>http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1</ref>
**'Skeletal do not touch list' <ref>URL: [http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1 http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1]. Accessed on: October 14, 2014.</ref>
*Pathologic
*Pathologic
**Giant cell lesions of bone.
**Giant cell lesions of bone.
Line 85: Line 85:


==Syndromes==
==Syndromes==
Jaffe-Campanacci syndrome <ref>{{http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome}}</ref>
Jaffe-Campanacci syndrome <ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref>


==Clinical history==
==Clinical history==

Revision as of 13:08, 14 October 2014

Metaphyseal fibrous defect
Diagnosis in short

Synonyms Nonossifying fibroma
Clinical history Incidental radiograhic finding
Radiology Lucent defect


General

  • Common
  • Non-neoplastic
  • Self-limited
  • Skeletally immature individuals, children and adolescent
  • Often small lesions discovered as an radiographic incidentaloma
  • Rarely seen as a pathologic specimen (should not be biopsied)

Synonyms

  • Nonossifying fibroma (larger but otherwise identical)
  • Fibrous cortical defect
  • Fibrous metaphyseal defect
  • Fibroxanthoma of bone

Site

  • Metaphysis of distal femur or proximal tibia (80%)
  • Cortical
  • Metaphysis
  • Long bones
  • Eccentric location

Gross

Firm, granular, brown to yellow to red

Microscopic

Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.

Differential Diagnosis

Relevant Diagnostic Groups

  • Clinical
    • FOG MACHINES - acronym for radiographically lytic bone lesions [1]
    • 'Skeletal do not touch list' [2]
  • Pathologic
    • Giant cell lesions of bone.
    • Spindle cell lesions of bone.

Images

Stains

Not relevant.

IHC

Not relevant

Molecular

Not relevant

Syndromes

Jaffe-Campanacci syndrome [3]

Clinical history

  • Incidental radiographic finding
  • Pathologic fracture

Prognosis

  • Ideally should not be biopsied
  • Radiographically characteristic and benign
  • Ideally should not be treated or even biopsied
  • Spontaneously resolve by ossification
  • May resolve into a 'bone island'

Radiographic findings

Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone

Sign out

BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.

See also

References