Difference between revisions of "Acquired cystic disease-associated renal cell carcinoma"
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*[[Acquired cystic renal disease]]. | *[[Acquired cystic renal disease]]. | ||
*[[Papillary renal cell carcinoma]]. | *[[Papillary renal cell carcinoma]]. | ||
*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]. | |||
==IHC== | ==IHC== | ||
Revision as of 18:50, 9 October 2014
Acquired cystic disease-associated renal cell carcinoma, abbreviated ACD-RCC, is a rare kidney cancer that arises in the context of chronic renal failure.
General
- Arise in the context of long-standing end-stage renal disease (ESRD).[1]
Gross
- Cysts.
Microscopic
Features:
- Tubular strucutres with cribriforming/a sieve-like architecture.[2]
- Hobnail cells.
- Oxylate crystals - important.
- Look somewhat like cholesterol clefts.
DDx:
- Acquired cystic renal disease.
- Papillary renal cell carcinoma.
- Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma.
IHC
Features:[1]
- AMACR +ve.
- CD10 +ve.
- Pankeratin +ve.
- CK7 +ve (heterogeneous).
Others:[1]
- CD68 -ve.
- PAX2 -ve.
See also
References
- ↑ 1.0 1.1 1.2 Ahn, S.; Kwon, GY.; Cho, YM.; Jun, SY.; Choi, C.; Kim, HJ.; Park, YW.; Park, WS. et al. (Mar 2013). "Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features.". Med Mol Morphol. doi:10.1007/s00795-013-0028-x. PMID 23471757.
- ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.