Difference between revisions of "Tubulocystic carcinoma of the kidney"

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It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal  | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref>
It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal  | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref>
It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]].


==General==
==General==

Revision as of 21:29, 22 August 2014

Tubulocystic carcinoma of the kidney
Diagnosis in short
Synonyms low-grade collecting duct carcinoma
LM cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
LM DDx renal oncocytoma, cystic nephroma/mixed epithelial and stromal tumour, multilocular cystic renal cell carcinoma
IHC CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve
Gross multicystic lesion (bubble wrap-like appearance)
Site kidney
Clinical history typically male
Prevalence very rare
Prognosis good

Tubulocystic carcinoma of the kidney, abbreviated TCCK, is a very rare kidney tumour.

It is also known as low-grade collecting duct carcinoma.[1]

It should not be confused with collecting duct carcinoma, a very aggressive renal tumour.

General

  • Not in the WHO classification of renal tumours - as of 2013.[2]
  • Rare <1% - in a series of 615 cases.
  • Males:Females ~ 7:1.[1]
  • Prognosis - probably favourable.[1]

Gross

  • Bubble wrap-like appearance - due to the cystic nature.[1]

Microscopic

Features:.[1]

  • Cysts of variable size lined by a single layer of epithelium that has a:
    • Cuboidal, flat, or hobnail morphology.
    • Eosinophilic cytoplasm.
    • Large nuclei with prominent nucleoli.
  • +/-Fibrotic stroma.

DDx:

Images

IHC

Features:[2]

  • CD10 +ve.
  • RCC +ve.
  • Vimentin +ve.
  • AMACR +ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Amin, MB.; MacLennan, GT.; Gupta, R.; Grignon, D.; Paraf, F.; Vieillefond, A.; Paner, GP.; Stovsky, M. et al. (Mar 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.". Am J Surg Pathol 33 (3): 384-92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562.
  2. ↑ 2.0 2.1 Alexiev, BA.; Drachenberg, CB. (May 2013). "Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study.". Virchows Arch 462 (5): 575-81. doi:10.1007/s00428-013-1398-0. PMID 23525677.
  3. ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
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