Difference between revisions of "Atrophy of the prostate gland"
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==General== | ==General== | ||
*Small glands (may mimic Gleason score 3 pattern). | *Small glands (may mimic Gleason score 3 pattern). | ||
*Inflammatory atrophy seems to be related to [[HGPIN]] and [[prostate cancer]];<ref name=pmid10595928>{{Cite journal | last1 = De Marzo | first1 = AM. | last2 = Marchi | first2 = VL. | last3 = Epstein | first3 = JI. | last4 = Nelson | first4 = WG. | title = Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. | journal = Am J Pathol | volume = 155 | issue = 6 | pages = 1985-92 | month = Dec | year = 1999 | doi = 10.1016/S0002-9440(10)65517-4 | PMID = 10595928 }}</ref> however, the epidemiology is not compelling that this is a significant (clinical) association.<ref name=pmid24129226>{{Cite journal | last1 = Celma | first1 = A. | last2 = Servián | first2 = P. | last3 = Planas | first3 = J. | last4 = Placer | first4 = J. | last5 = Quilez | first5 = MT. | last6 = Arbós | first6 = MA. | last7 = de Torres | first7 = I. | last8 = Morote | first8 = J. | title = Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy. | journal = Actas Urol Esp | volume = 38 | issue = 2 | pages = 122-126 | month = Mar | year = 2014 | doi = 10.1016/j.acuro.2013.04.008 | PMID = 24129226 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 01:56, 29 April 2014
Atrophy of the prostate gland, also prostatic atrophy, is a common change in the prostate gland.
It usually is seen focally; thus, it is sometimes called partial prostatic atrophy.
On occasion, it can mimic prostate carcinoma, especially atrophic prostate carcinoma.
General
- Small glands (may mimic Gleason score 3 pattern).
- Inflammatory atrophy seems to be related to HGPIN and prostate cancer;[1] however, the epidemiology is not compelling that this is a significant (clinical) association.[2]
Microscopic
Features:
- Glands often have a jagged edges/prows (in cancer the glands tend to have round edges) - key feature.
- Prow = forward most part of a ship's bow that cuts through the water.[3]
- You may have come across prow in the context of breast cancer, i.e. tubular carcinoma.
- Prow = forward most part of a ship's bow that cuts through the water.[3]
- Gland density is usually lower than in prostate carcinoma, i.e. glands are not back-to-back - key feature.
- Atrophic glands are often hyperchromatic.[4]
- Scant cytoplasm - usually.
Negatives:
- Nuclei like normal, i.e. nucleoli uncommon.
- Should have two cell layers, i.e. epithelial and myoepithelial (may be difficult to see).
Notes:
- Atrophic glands may be scattered with non-atrophic ones.
- IHC may be misleading - basal cell loss.
DDx:
Atrophy versus cancer
| Histologic feature | Atrophy | Cancer |
|---|---|---|
| Glandular architecture/ arrangement |
angulated glands, may look like they originate from one large duct |
round glands, often back-to-back |
| Nuclear hyperchromasia |
marked | moderate |
| Cytoplasm | scant/minimal | moderate, may be amphophilic |
| Basal cells | may be visible | absent |
| Nucleoli | absent | present |
| Secretions in glands |
no | yes - eosinophilic or blue |
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Generally, this finding is not reported; it is considered a normal finding.
See also
References
- ↑ De Marzo, AM.; Marchi, VL.; Epstein, JI.; Nelson, WG. (Dec 1999). "Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis.". Am J Pathol 155 (6): 1985-92. doi:10.1016/S0002-9440(10)65517-4. PMID 10595928.
- ↑ Celma, A.; Servián, P.; Planas, J.; Placer, J.; Quilez, MT.; Arbós, MA.; de Torres, I.; Morote, J. (Mar 2014). "Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy.". Actas Urol Esp 38 (2): 122-126. doi:10.1016/j.acuro.2013.04.008. PMID 24129226.
- ↑ http://en.wikipedia.org/wiki/Prow
- ↑ SN. June 3, 2009.