Difference between revisions of "Apocrine carcinoma of the breast"
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| Micro = cells with prominent [[nucleoli]] - may be multiple, abundant granular eosinophilic cytoplasm, loss of basal cells | | Micro = cells with prominent [[nucleoli]] - may be multiple, abundant granular eosinophilic cytoplasm, loss of basal cells | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[glycogen-rich clear cell carcinoma of the breast]] | ||
| Stains = | | Stains = | ||
| IHC = AR +ve, [[GCDFP-15]] +ve, ER -ve, PR -ve | | IHC = AR +ve, [[GCDFP-15]] +ve, ER -ve, PR -ve | ||
| Line 41: | Line 41: | ||
*Abundant granular eosinophilic cytoplasm. | *Abundant granular eosinophilic cytoplasm. | ||
*Architecture like invasive ductal carcinomas ''no special type''. | *Architecture like invasive ductal carcinomas ''no special type''. | ||
DDx: | |||
*[[Glycogen-rich clear cell carcinoma of the breast]]. | |||
===Images=== | ===Images=== | ||
Revision as of 19:11, 14 February 2014
| Apocrine carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | cells with prominent nucleoli - may be multiple, abundant granular eosinophilic cytoplasm, loss of basal cells |
| LM DDx | glycogen-rich clear cell carcinoma of the breast |
| IHC | AR +ve, GCDFP-15 +ve, ER -ve, PR -ve |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | uncommon |
Apocrine carcinoma of the breast is a rare form of invasive breast cancer.
General
- Need >=90% apocrine morphology.[1]
Microscopic
Features:[1]
- Prominent nucleoli.
- Often multiple.[2]
- Abundant granular eosinophilic cytoplasm.
- Architecture like invasive ductal carcinomas no special type.
DDx:
Images
www:
IHC
Smaller tumours classically:[3]
- AR +ve.
- GCDFP-15 +ve.
Usually:[1]
- ER -ve.
- PR -ve.
See also
References
- ↑ 1.0 1.1 1.2 O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066801.
- ↑ O'Malley, FP.; Bane, A. (Jan 2008). "An update on apocrine lesions of the breast.". Histopathology 52 (1): 3-10. doi:10.1111/j.1365-2559.2007.02888.x. PMID 18171412.
- ↑ Honma, N.; Takubo, K.; Akiyama, F.; Sawabe, M.; Arai, T.; Younes, M.; Kasumi, F.; Sakamoto, G. (Aug 2005). "Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.". Histopathology 47 (2): 195-201. doi:10.1111/j.1365-2559.2005.02181.x. PMID 16045781.