Difference between revisions of "Sex cord tumour with annular tubules"

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==IHC==
==IHC==
Features:<ref name=pmid19703688>{{Cite journal  | last1 = Nosov | first1 = V. | last2 = Park | first2 = S. | last3 = Rao | first3 = J. | last4 = Memarzadeh | first4 = S. | title = Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. | journal = Fertil Steril | volume = 92 | issue = 4 | pages = 1497.e5-8 | month = Oct | year = 2009 | doi = 10.1016/j.fertnstert.2009.07.1002 | PMID = 19703688 }}</ref>
Features:<ref name=pmid19703688>{{Cite journal  | last1 = Nosov | first1 = V. | last2 = Park | first2 = S. | last3 = Rao | first3 = J. | last4 = Memarzadeh | first4 = S. | title = Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. | journal = Fertil Steril | volume = 92 | issue = 4 | pages = 1497.e5-8 | month = Oct | year = 2009 | doi = 10.1016/j.fertnstert.2009.07.1002 | PMID = 19703688 }}</ref>
*Inhibin +ve.<ref>{{Cite journal  | last1 = Guerrieri | first1 = C. | last2 = Frånlund | first2 = B. | last3 = Malmström | first3 = H. | last4 = Boeryd | first4 = B. | title = Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. | journal = Int J Gynecol Pathol | volume = 17 | issue = 3 | pages = 266-71 | month = Jul | year = 1998 | doi =  | PMID = 9656124 }}</ref>
*Inhibin +ve<ref>{{Cite journal  | last1 = Guerrieri | first1 = C. | last2 = Frånlund | first2 = B. | last3 = Malmström | first3 = H. | last4 = Boeryd | first4 = B. | title = Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. | journal = Int J Gynecol Pathol | volume = 17 | issue = 3 | pages = 266-71 | month = Jul | year = 1998 | doi =  | PMID = 9656124 }}</ref> (3/3<ref name=pmid12808064/>).
*Calretinin +ve.
*Calretinin +ve (3/3<ref name=pmid12808064/>).
*CD99 +ve.
*CD99 +ve.
*Pankeratin +ve.
*Pankeratin +ve.
Line 79: Line 79:
*AFP -ve.
*AFP -ve.
*CD10 -ve.
*CD10 -ve.
*EMA -ve (0/3<ref name=pmid12808064>{{Cite journal  | last1 = Deavers | first1 = MT. | last2 = Malpica | first2 = A. | last3 = Liu | first3 = J. | last4 = Broaddus | first4 = R. | last5 = Silva | first5 = EG. | title = Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin. | journal = Mod Pathol | volume = 16 | issue = 6 | pages = 584-90 | month = Jun | year = 2003 | doi = 10.1097/01.MP.0000073133.79591.A1 | PMID = 12808064 }}</ref>).
*WT1 +ve (3/3<ref name=pmid12808064/>).


==See also==
==See also==

Revision as of 03:25, 14 February 2014

Sex cord tumour with annular tubules
Diagnosis in short

SCTAT. H&E stain.
LM well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material
Subtypes benign, malignant (very rare)
LM DDx Sertoli-Leydig tumour, granulosa cell tumour, Brenner tumour
Site ovary - see ovarian tumours
Syndromes Peutz-Jeghers syndrome
Prevalence uncommon
Prognosis usually good (benign)
Clin. DDx other ovarian tumours

Sex cord tumour with annular tubules, abbreviated SCTAT, is an uncommon sex cord tumour.

It is not sex cord tumour with angulated tubules.

General

  • Associated with Peutz-Jeghers syndrome.[1]
    • Large tumours more likely sporadic.
    • Small tumours more likely Peutz-Jeghers syndrome and incidental.
  • Usually benign.
    • Malignant cases reported.[2]

Microscopic

Features:

  • Well-circumscribed nests of cells with nuclei at the periphery.
  • Annular tubules (ring-shaped tubules) with dense hyaline material.

Notes:

DDx:

Images

www:

  • SCTAT - intermed. mag. (WC)

  • SCTAT - high mag. (WC)

  • SCTAT - very high mag. (WC)

  • SCTAT - very high mag. (WC)

IHC

Features:[5]

  • Inhibin +ve[6] (3/3[7]).
  • Calretinin +ve (3/3[7]).
  • CD99 +ve.
  • Pankeratin +ve.
  • Vimentin +ve.

Others:

  • S-100 -ve.
  • AFP -ve.
  • CD10 -ve.
  • EMA -ve (0/3[7]).
  • WT1 +ve (3/3[7]).

See also

References

  1. ↑ Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
  2. ↑ Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
  3. ↑ URL: http://dictionary.reference.com/browse/annular. Accessed on: 6 August 2011.
  4. ↑ Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.
  5. ↑ Nosov, V.; Park, S.; Rao, J.; Memarzadeh, S. (Oct 2009). "Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report.". Fertil Steril 92 (4): 1497.e5-8. doi:10.1016/j.fertnstert.2009.07.1002. PMID 19703688.
  6. ↑ Guerrieri, C.; Frånlund, B.; Malmström, H.; Boeryd, B. (Jul 1998). "Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7.". Int J Gynecol Pathol 17 (3): 266-71. PMID 9656124.
  7. ↑ 7.0 7.1 7.2 7.3 Deavers, MT.; Malpica, A.; Liu, J.; Broaddus, R.; Silva, EG. (Jun 2003). "Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin.". Mod Pathol 16 (6): 584-90. doi:10.1097/01.MP.0000073133.79591.A1. PMID 12808064.
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