Difference between revisions of "Pseudoangiomatous stromal hyperplasia"
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| Caption = Pseudoangiomatous stromal hyperplasia. [[H&E stain]]. | | Caption = Pseudoangiomatous stromal hyperplasia. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = abundant breast stroma, small complex inter-anastomosing (blood vessel/capillary-like) channels | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[fibroadenoma]], low-grade [[angiosarcoma]] | | LMDDx = [[fibroadenoma]], low-grade [[angiosarcoma]] | ||
Revision as of 00:38, 1 February 2014
| Pseudoangiomatous stromal hyperplasia | |
|---|---|
| Diagnosis in short | |
 Pseudoangiomatous stromal hyperplasia. H&E stain. | |
|
| |
| LM | abundant breast stroma, small complex inter-anastomosing (blood vessel/capillary-like) channels |
| LM DDx | fibroadenoma, low-grade angiosarcoma |
| Stains | Bcl-2 +ve, vimentin +ve, CD34 -ve, CD31 -ve, factor VIII -ve |
| Site | breast |
|
| |
| Signs | +/-breast mass |
| Prevalence | uncommon |
| Prognosis | benign |
| Clin. DDx | fibroadenoma |
| Treatment | excision |
Pseudoangiomatous stromal hyperplasia, abbreviated PASH, is benign lesion is breast pathology.
It is also known as nodular myofibroblastic stromal hyperplasia of the mammary gland.[1]
General
- Benign lesion.
- Thought to arise due to myofibroblast abnormality - though not well understood.[2]
- Often an incidental finding.
Gross
Features:[2]
- May form mass: grey-white & firm, with well circumscribed borders.
Microscopic
- Abundant breast stromal.
- Small, complex, inter-anastomosing (blood vessel/capillary-like) channels - key feature.
- Pseudoangiomatous = blood vessel-like.
Notes:
- May mimic angiosarcoma at low power; PASH may have the same architecture but lack nuclear atypia.
DDx:
Images
PASH - low mag. (WC/Nephron)
PASH - intermed. mag. (WC/Nephron)
PASH - high mag. (WC/Nephron)
www:
IHC
Findings:[2]
See also
References
- ↑ Leon, ME.; Leon, MA.; Ahuja, J.; Garcia, FU.. "Nodular myofibroblastic stromal hyperplasia of the mammary gland as an accurate name for pseudoangiomatous stromal hyperplasia of the mammary gland.". Breast J 8 (5): 290-3. PMID 12199757.
- ↑ 2.0 2.1 2.2 Powell CM, Cranor ML, Rosen PP (March 1995). "Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation". Am. J. Surg. Pathol. 19 (3): 270–7. PMID 7872425.
- ↑ Vuitch MF, Rosen PP, Erlandson RA (February 1986). "Pseudoangiomatous hyperplasia of mammary stroma". Hum. Pathol. 17 (2): 185–91. PMID 3949338.
- ↑ 4.0 4.1 Ferreira, M.; Albarracin, CT.; Resetkova, E. (Feb 2008). "Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases.". Mod Pathol 21 (2): 201-7. doi:10.1038/modpathol.3801003. PMID 18084246.
- ↑ 5.0 5.1 Baker, M.; Chen, H.; Latchaw, L.; Memoli, V.; Ornvold, K. (Aug 2011). "Pseudoangiomatous stromal hyperplasia of the breast in a 10-year-old girl.". J Pediatr Surg 46 (8): e27-31. doi:10.1016/j.jpedsurg.2011.04.063. PMID 21843705.
- ↑ URL: http://surgpathcriteria.stanford.edu/breast/pash/printable.html. Accessed on: 28 April 2012.