Difference between revisions of "Zoon vulvitis"
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'''Zoon vulvitis''', also '''vulvitis circumscripta plasmacellularis'''<ref>{{Cite journal | last1 = dos Reis | first1 = HL. | last2 = de Vargas | first2 = PR. | last3 = Lucas | first3 = E. | last4 = Camporez | first4 = T. | last5 = Ferreira | first5 = Dde C. | title = Zoon vulvitis as a differential diagnosis in an HIV-infected patient: a short report. | journal = J Int Assoc Provid AIDS Care | volume = 12 | issue = 3 | pages = 159-61 | month = | year = | doi = 10.1177/2325957412467694 | PMID = 23449712 }}</ref> and '''plasma cell vulvitis''', is a rare pathology of the [[vulva]]. | '''Zoon vulvitis''', also '''vulvitis circumscripta plasmacellularis'''<ref>{{Cite journal | last1 = dos Reis | first1 = HL. | last2 = de Vargas | first2 = PR. | last3 = Lucas | first3 = E. | last4 = Camporez | first4 = T. | last5 = Ferreira | first5 = Dde C. | title = Zoon vulvitis as a differential diagnosis in an HIV-infected patient: a short report. | journal = J Int Assoc Provid AIDS Care | volume = 12 | issue = 3 | pages = 159-61 | month = | year = | doi = 10.1177/2325957412467694 | PMID = 23449712 }}</ref> and '''plasma cell vulvitis''', is a rare pathology of the [[vulva]]. | ||
It is also known as ''[[plasmacytosis mucosae]]'',<ref name=Ref_GP11>{{Ref GP|11}}</ref> which may be used to refer to ''[[Zoon balanitis]]''. | |||
==General== | ==General== | ||
Revision as of 20:50, 3 January 2014
Zoon vulvitis, also vulvitis circumscripta plasmacellularis[1] and plasma cell vulvitis, is a rare pathology of the vulva.
It is also known as plasmacytosis mucosae,[2] which may be used to refer to Zoon balanitis.
General
- Rare ~ 50 reported cases in English literature as of 2012.[3]
- Analogous to Zoon's balanitis in males.[4]
Clinical:[3]
- Pruritis.
- Pain.
Gross
Features:[3]
- Erythematous macules or papules.
Microscopic
Features:
- Squamous epithelium with:[2]
- Spongiosis.
- Lack of stratum granulosum and stratum corneum layers.
- "Lozenge"-shaped (diamond-like shape).
- Abundant plasma cells - esp. superficial dermis.
- Hemosiderin deposits.[5]
DDx:
- Syphilis.
- Lichenoid drug reaction.
Images
IHC
- CD138 -- to highlight plasma cells.
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LESION, VULVA, BIOPSY: - SQUAMOUS MUCOSA WITHOUT A CORNIFIED ZONE, WITH MARKED CHRONIC INFLAMMATION WITH PROMINENT PLASMA CELLS, SEE COMMENT. - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. COMMENT: The loss of the cornified zone and prominent plasma cells is consistent with plasma cell vulvitis (Zoon vulvitis). Clinical correlation is suggested. A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain is negative. Ki-67 positive cells are basal. No microorganisms are apparent with a PASF stain.
See also
References
- ↑ dos Reis, HL.; de Vargas, PR.; Lucas, E.; Camporez, T.; Ferreira, Dde C.. "Zoon vulvitis as a differential diagnosis in an HIV-infected patient: a short report.". J Int Assoc Provid AIDS Care 12 (3): 159-61. doi:10.1177/2325957412467694. PMID 23449712.
- ↑ 2.0 2.1 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 11. ISBN 978-0443069208.
- ↑ 3.0 3.1 3.2 3.3 Çelik, A.; Haliloglu, B.; Tanriöver, Y.; Ilter, E.; Gündüz, T.; Ulu, I.; Midi, A.; Özekici, Ü.. "Plasma cell vulvitis: a vulvar itching dilemma.". Indian J Dermatol Venereol Leprol 78 (2): 230. doi:10.4103/0378-6323.93664. PMID 22421677.
- ↑ Yoganathan, S.; Bohl, TG.; Mason, G. (Dec 1994). "Plasma cell balanitis and vulvitis (of Zoon). A study of 10 cases.". J Reprod Med 39 (12): 939-44. PMID 7884748.
- ↑ Davis, J.; Shapiro, L.; Baral, J. (Mar 1983). "Vulvitis circumscripta plasmacellularis.". J Am Acad Dermatol 8 (3): 413-6. PMID 6833541.