Difference between revisions of "Serous carcinoma of the ovary"
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Image:Serous_carcinoma_cytology.jpg | Serous carcinoma - cytology. (WC) | Image:Serous_carcinoma_cytology.jpg | Serous carcinoma - cytology. (WC) | ||
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*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716424/figure/F1/ Serous carcinoma - grade 1, 2 and 3 (nih.gov)].<ref name=pmid19461510>{{Cite journal | last1 = Ayhan | first1 = A. | last2 = Kurman | first2 = RJ. | last3 = Yemelyanova | first3 = A. | last4 = Vang | first4 = R. | last5 = Logani | first5 = S. | last6 = Seidman | first6 = JD. | last7 = Shih | first7 = IeM. | title = Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. | journal = Am J Surg Pathol | volume = 33 | issue = 8 | pages = 1220-4 | month = Aug | year = 2009 | doi = 10.1097/PAS.0b013e3181a24354 | PMID = 19461510 }}</ref> | |||
==IHC== | ==IHC== | ||
Revision as of 22:27, 1 January 2014
Serous carcinoma of the ovary, also ovarian serous carcinoma, is relatively common malignant ovarian tumour.
General
- Most common malignant ovarian tumour in the eldery.
- Poor prognosis.
- Thought to arise from serous tubal intraepithelial carcinoma (STIC).[1]
Microscopic
Features:
- Marked nuclear pleomorphism:
- Variation in size - usually marked.
- Variation in staining.
- Variation in shape.
- Prominent nucleolus - key feature.
- Eccentric nucleus.
- Architecture:
- Solid.
- Papillary - classic.
- Glandular - uncommon.
- +/-Psammoma bodies - uncommon.
- +/-Necrosis - often extensive.
DDx:
- Clear cell carcinoma of the ovary - less nuclear size variation.
- Endometrioid carcinoma of the ovary - usu. lower grade.
- Primary peritoneal serous carcinoma - bulk of tumour in peritoneum, small ovarian tumour.
- Other non-ovarian serous carcinomas - see serous carcinoma.
- Ovarian serous borderline tumour - mild to moderate nuclear atypia, no invasion, few mitoses.
Grading
Serous carcinoma is subdivided into:[2][3]
- Low-grade (Type I).
- High-grade (Type II).
Note:
- Tumours very rarely transform from low-grade to high-grade.[2]
Images
Serous carcinoma - cytology. (WC)
www:
IHC
Others:
- HNF-1beta -ve.[7][8]
- Usually +ve in clear cell carcinoma of the ovary.
See also
References
- ↑ Vang, R.; Shih, IeM.; Kurman, RJ. (Jan 2013). "Fallopian tube precursors of ovarian low- and high-grade serous neoplasms.". Histopathology 62 (1): 44-58. doi:10.1111/his.12046. PMID 23240669.
- ↑ 2.0 2.1 Garg, K.; Park, KJ.; Soslow, RA. (Sep 2012). "Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: a report of 3 cases.". Int J Gynecol Pathol 31 (5): 423-8. doi:10.1097/PGP.0b013e31824ae6f2. PMID 22833081.
- ↑ Vang, R.; Shih, IeM.; Kurman, RJ. (Sep 2009). "Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems.". Adv Anat Pathol 16 (5): 267-82. doi:10.1097/PAP.0b013e3181b4fffa. PMID 19700937.
- ↑ Ayhan, A.; Kurman, RJ.; Yemelyanova, A.; Vang, R.; Logani, S.; Seidman, JD.; Shih, IeM. (Aug 2009). "Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis.". Am J Surg Pathol 33 (8): 1220-4. doi:10.1097/PAS.0b013e3181a24354. PMID 19461510.
- ↑ Köbel, M.; Kalloger, SE.; Carrick, J.; Huntsman, D.; Asad, H.; Oliva, E.; Ewanowich, CA.; Soslow, RA. et al. (Jan 2009). "A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary.". Am J Surg Pathol 33 (1): 14-21. doi:10.1097/PAS.0b013e3181788546. PMID 18830127.
- ↑ DeLair, D.; Oliva, E.; Köbel, M.; Macias, A.; Gilks, CB.; Soslow, RA. (Jan 2011). "Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases.". Am J Surg Pathol 35 (1): 36-44. doi:10.1097/PAS.0b013e3181ff400e. PMID 21164285.
- ↑ Tsuchiya, A.; Sakamoto, M.; Yasuda, J.; Chuma, M.; Ohta, T.; Ohki, M.; Yasugi, T.; Taketani, Y. et al. (Dec 2003). "Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.". Am J Pathol 163 (6): 2503-12. PMID 14633622. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 189907