Difference between revisions of "Talk:Uterine cervix"
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Exclusions: | Exclusions: | ||
*Cytoplasm to nucleus ratio =< 2:1; HSIL or invasive SCC. | *Cytoplasm to nucleus ratio =< 2:1; HSIL or invasive SCC. | ||
== Cannot exclude HSIL == | |||
<pre> | |||
UTERINE ENDOCERVIX, CURETTAGE: | |||
- VERY SMALL FRAGMENTS WITH AT LEAST LOW-GRADE SQUAMOUS INTRAEPITHELIAL | |||
LESION (LSIL), SEE COMMENT. | |||
- STRIPPED ENDOCERVICAL EPITHELIUM WITHOUT APPARENT PATHOLOGY. | |||
COMMENT: | |||
The morphology is more in keeping with LSIL; however, a p16 stain shows strong diffuse | |||
staining, as may be seen in the basal cells of a LSIL or a high-grade squamous | |||
intraepithelial lesion (HSIL). HSIL cannot be excluded. | |||
</pre> | |||
Revision as of 20:45, 18 November 2013
LSIL criteria
The London (cytology) criteria - 2 of 3:
- Perinuclear clearing.
- Membrane irregularities (5 cells in one field - FD ~ 1.1 mm).
- Nuclear enlargement > 2x lymphocyte.
Augmented (London) criterium includes:
- Neoplastic transisition (sharp transisition from normal to abnormal - gradient over 2-3 cell distance).
Required if #3 not obvious:
- Binucleation (>2 cells).
Relative exclusions:
- Nucleoli ( >5 in one field - FD ~ 1.1 mm).
Exclusions:
- Cytoplasm to nucleus ratio =< 2:1; HSIL or invasive SCC.
Cannot exclude HSIL
UTERINE ENDOCERVIX, CURETTAGE: - VERY SMALL FRAGMENTS WITH AT LEAST LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (LSIL), SEE COMMENT. - STRIPPED ENDOCERVICAL EPITHELIUM WITHOUT APPARENT PATHOLOGY. COMMENT: The morphology is more in keeping with LSIL; however, a p16 stain shows strong diffuse staining, as may be seen in the basal cells of a LSIL or a high-grade squamous intraepithelial lesion (HSIL). HSIL cannot be excluded.