Difference between revisions of "Tumour budding"
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==Microscopic== | ==Microscopic== | ||
Definitions: | Definitions: | ||
*Tumour bud = 1-4 cell(s). | *Tumour bud = 1-4 cell(s) -- at the tumour front. | ||
*"High-grade budding" is >=10 tumour buds in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | *"High-grade budding" is >=10 tumour buds in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | ||
Note: | Note: | ||
*If the microscope has a 22 mm eye piece and... | *If the microscope has a 22 mm eye piece and... | ||
**A 20x objective, the field is approximately 0.950 mm<sup>2</sup> -- to match the area | **A 20x objective, the field is approximately 0.950 mm<sup>2</sup> -- to match the buds/area -- it would be 24.68 buds/0.950 mm<sup>2</sup>. | ||
**A 40x objective, the field is approximately 0.238 mm<sup>2</sup> -- to match the area | **A 40x objective, the field is approximately 0.238 mm<sup>2</sup> -- to match the buds/area -- it would be 6.17 buds/0.238 mm<sup>2</sup>. | ||
===Images=== | ===Images=== | ||
Revision as of 11:43, 17 November 2013
Tumour budding refers to lone tumour cells or small clusters of tumour cells at the advancing front of a tumour.[1]
Microscopic
Definitions:
- Tumour bud = 1-4 cell(s) -- at the tumour front.
- "High-grade budding" is >=10 tumour buds in a field of 0.385 mm2.[1]
Note:
- If the microscope has a 22 mm eye piece and...
- A 20x objective, the field is approximately 0.950 mm2 -- to match the buds/area -- it would be 24.68 buds/0.950 mm2.
- A 40x objective, the field is approximately 0.238 mm2 -- to match the buds/area -- it would be 6.17 buds/0.238 mm2.
Images
Tumour budding in CRC - intermed. mag. (WC)
Tumour budding in CRC - high mag. (WC)
Tumour budding in CRC - very high mag. (WC)
