Difference between revisions of "Collecting duct carcinoma"

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#redirect [[Kidney_tumours#Collecting_duct_carcinoma]]
'''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal  | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month =  | year =  | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]].
 
==General==
*Rare.
*Poor prognosis.
*Usu. central location.
*Typically young adults.
 
==Microscopic==
Features:<ref name=Ref_GUP295>{{Ref GUP|295}}</ref>
*Tubular structures with tapered ends.
**May be described as ''tubulopapillary''.
*[[Hobnail pattern]] - cell width smaller at basement membrane than free surface.<ref name=Ref_PBoD1018>{{Ref PBoD|1018}}</ref>
*High grade nuclear features (nuclear pleomorphism).
*High mitotic rate.
 
Notes:
*Benign urothelium must present to excluded urothelial carcinoma.
*Desmoplastic stroma may be prominent.
 
DDx:
*[[Papillary renal cell carcinoma]] - type 2.
*[[Urothelial carcinoma]] with glandular differentiation.
*Metastatic [[adenocarcinoma]].
*[[Renal medullary carcinoma]] - typically younger, sickle cell trait.
 
===Images===
www:
*[http://webpathology.com/image.asp?case=69&n=1 CDC (webpathology.com)].
*[http://webpathology.com/image.asp?n=2&Case=69 CDC - showing hobnail pattern (webpathology.com)].
*[http://radiographics.rsna.org/content/26/6/1795/F17.expansion.html CDC (rsna.org)].<ref name=pmid17102051>{{Cite journal  | last1 = Prasad | first1 = SR. | last2 = Humphrey | first2 = PA. | last3 = Catena | first3 = JR. | last4 = Narra | first4 = VR. | last5 = Srigley | first5 = JR. | last6 = Cortez | first6 = AD. | last7 = Dalrymple | first7 = NC. | last8 = Chintapalli | first8 = KN. | title = Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. | journal = Radiographics | volume = 26 | issue = 6 | pages = 1795-806; discussion 1806-10 | month =  | year =  | doi = 10.1148/rg.266065010 | PMID = 17102051 }}</ref>
 
==IHC==
Features:<ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 | URL = http://www.nature.com/modpathol/journal/v22/n2s/full/modpathol200970a.html }}</ref>
*HMWCK +ve.
*LMWCK +ve.
*CD117 +ve.
*E-cadherin +ve.
*CD10 -ve.
*AMACR -ve.
 
UCC:
*CK20 +ve.<ref name=pmid19494850/>
*p63 +ve.
*CK5/6 +ve.
 
Others:
*CK7 +ve.<ref name=pmid12613443>{{Cite journal  | last1 = Kim | first1 = MK. | last2 = Kim | first2 = S. | title = Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | journal = Appl Immunohistochem Mol Morphol | volume = 10 | issue = 4 | pages = 332-8 | month = Dec | year = 2002 | doi =  | PMID = 12613443 }}</ref>
 
==See also==
*[[Kidney tumours]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Kidney tumours]]

Revision as of 03:36, 4 November 2013

Collecting duct carcinoma, also known as Bellini duct carcinoma[1] and carcinoma of the collecting ducts of Bellini, is a rare aggressive kidney tumour.

General

  • Rare.
  • Poor prognosis.
  • Usu. central location.
  • Typically young adults.

Microscopic

Features:[2]

  • Tubular structures with tapered ends.
    • May be described as tubulopapillary.
  • Hobnail pattern - cell width smaller at basement membrane than free surface.[3]
  • High grade nuclear features (nuclear pleomorphism).
  • High mitotic rate.

Notes:

  • Benign urothelium must present to excluded urothelial carcinoma.
  • Desmoplastic stroma may be prominent.

DDx:

Images

www:

IHC

Features:[5]

  • HMWCK +ve.
  • LMWCK +ve.
  • CD117 +ve.
  • E-cadherin +ve.
  • CD10 -ve.
  • AMACR -ve.

UCC:

  • CK20 +ve.[5]
  • p63 +ve.
  • CK5/6 +ve.

Others:

See also

References

  1. ↑ Stamatiou, K.; Zizi-Sermpetzoglou, A.. "Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis.". Indian J Pathol Microbiol 54 (1): 229-30. doi:10.4103/0377-4929.77425. PMID 21393935.
  2. ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 295. ISBN 978-0443066771.
  3. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1018. ISBN 0-7216-0187-1.
  4. ↑ Prasad, SR.; Humphrey, PA.; Catena, JR.; Narra, VR.; Srigley, JR.; Cortez, AD.; Dalrymple, NC.; Chintapalli, KN.. "Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation.". Radiographics 26 (6): 1795-806; discussion 1806-10. doi:10.1148/rg.266065010. PMID 17102051.
  5. ↑ 5.0 5.1 Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
  6. ↑ Kim, MK.; Kim, S. (Dec 2002). "Immunohistochemical profile of common epithelial neoplasms arising in the kidney.". Appl Immunohistochem Mol Morphol 10 (4): 332-8. PMID 12613443.
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