Difference between revisions of "Diverticular disease"

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Features:<ref name=pmid19581849>{{Cite journal  | last1 = Mulhall | first1 = AM. | last2 = Mahid | first2 = SS. | last3 = Petras | first3 = RE. | last4 = Galandiuk | first4 = S. | title = Diverticular disease associated with inflammatory bowel disease-like colitis: a systematic review. | journal = Dis Colon Rectum | volume = 52 | issue = 6 | pages = 1072-9 | month = Jun | year = 2009 | doi = 10.1007/DCR.0b013e31819ef79a | PMID = 19581849 }}</ref>
Features:<ref name=pmid19581849>{{Cite journal  | last1 = Mulhall | first1 = AM. | last2 = Mahid | first2 = SS. | last3 = Petras | first3 = RE. | last4 = Galandiuk | first4 = S. | title = Diverticular disease associated with inflammatory bowel disease-like colitis: a systematic review. | journal = Dis Colon Rectum | volume = 52 | issue = 6 | pages = 1072-9 | month = Jun | year = 2009 | doi = 10.1007/DCR.0b013e31819ef79a | PMID = 19581849 }}</ref>
*Rare.
*Rare.
*Definitions vary somewhat - one is: ''IBD-like inflammation restricted to areas with diverticular disease''.
*Definitions vary somewhat - one is: ''[[IBD]]-like inflammation restricted to areas with diverticular disease''.
*Considerable overlap with IBD histologically (no definite histologic findings).
*Considerable overlap with IBD histologically - no definite histologic findings.
*Rectal biopsy may be used to differentiate from [[ulcerative colitis]].
*Rectal biopsy may be used to differentiate from [[ulcerative colitis]].


Line 90: Line 90:
*[[Colon]].
*[[Colon]].
*[[Gastrointestinal pathology]].
*[[Gastrointestinal pathology]].
*[[Inflammatory bowel disease]] (IBD).


==References==
==References==

Revision as of 18:28, 1 November 2013

Diverticular disease
Diagnosis in short

Diverticulum. H&E stain.

LM mucosa/submucosa invaginate into the musuclaris propria
Site colon, other sites

Associated Dx diverticulitis, peritonitis, diverticular-associated colitis
Symptoms usu. asymptomatic, diverticulitis presents with abdominal pain
Clin. DDx colorectal carcinoma

Diverticular disease, also diverticulosis, is a common disease of the colon. Inflammation of diverticula is known as diverticulitis.

General

  • Very common.
  • Typically seen in elderly patients - 50s and 60s.

Complications:

  • Diverticulitis.
  • Peformation - peritonitis.
  • Diverticular-associated colitis - see below.

Diverticular-associated colitis

Features:[1]

  • Rare.
  • Definitions vary somewhat - one is: IBD-like inflammation restricted to areas with diverticular disease.
  • Considerable overlap with IBD histologically - no definite histologic findings.
  • Rectal biopsy may be used to differentiate from ulcerative colitis.

Gross

  • Corrugated - like cardboard.
  • Wall thickening (reactive).[2]

Endoscopic image

Grossing notes

Microscopic

Features:

  • Mucosa/submucosa invagination into the musuclaris propria (MP).
    • At the site the blood vessels supplying the mucosa and submucosa penetrate the MP.[3]

DDx:

Images

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RECTO-SIGMOID, LARGE BOWEL RESECTION:
- PERFORATED DIVERTICULITIS WITH SEROSITIS AND ABSCESS FORMATION.
- SUBMUCOSAL FIBROSIS.
- ONE LYMPH NODE NEGATIVE FOR MALIGNANCY ( 0 POSITIVE / 1 ).
- NEGATIVE FOR MALIGNANCY.
SIGMOID COLON, SIGMOIDECTOMY:
- DIVERTICULAR DISEASE WITHOUT DIVERTICULITIS.
- NEGATIVE FOR MALIGNANCY.

See also

References

  1. Mulhall, AM.; Mahid, SS.; Petras, RE.; Galandiuk, S. (Jun 2009). "Diverticular disease associated with inflammatory bowel disease-like colitis: a systematic review.". Dis Colon Rectum 52 (6): 1072-9. doi:10.1007/DCR.0b013e31819ef79a. PMID 19581849.
  2. Nicholson, BD.; Hyland, R.; Rembacken, BJ.; Denyer, M.; Hull, MA.; Tolan, DJ. (Aug 2011). "Colonoscopy for colonic wall thickening at computed tomography: a worthwhile pursuit?". Surg Endosc 25 (8): 2586-91. doi:10.1007/s00464-011-1591-7. PMID 21359889.
  3. West, AB.. "The pathology of diverticulitis.". J Clin Gastroenterol 42 (10): 1137-8. doi:10.1097/MCG.0b013e3181862a9f. PMID 18936652.
  4. URL: http://histology-group28.wikispaces.com/DigestiveSystemProject. Accessed on: 23 August 2011.