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| ==Mammary myofibroblastoma== | | ==Mammary myofibroblastoma== |
| ===General===
| | {{Main|Mammary myofibroblastoma}} |
| *Rare.
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| *Excision = cure.
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| *Postmenopausal females and older males.<ref name=pmid18723968>{{Cite journal | last1 = Qureshi | first1 = A. | last2 = Kayani | first2 = N. | title = Myofibroblastoma of breast. | journal = Indian J Pathol Microbiol | volume = 51 | issue = 3 | pages = 395-6 | month = | year = | doi = | PMID = 18723968 }}</ref><ref name=pmid22096693>{{Cite journal | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month = | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 | PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/?tool=pubmed}}</ref>
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| Note:
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| *In extra-mammary sites the tumour is known as a ''mammary-type myofibroblastoma'' may immunohistochemically and histomorphologically overlap with [[spindle cell lipoma]].<ref name=pmid11474286>{{Cite journal | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi = | PMID = 11474286 }}</ref>
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| ===Microscopic===
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| Features:<ref name=Ref_BP131>{{Ref BP|131}}</ref>
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| *Well-circumscribed lesion.
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| *Spindle cells without nuclear atypia arranged in fascicles.
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| *Interspersed thick bundles of collagen.
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| Notes:
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| *No calcifications.
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| *No necrosis.
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| *No hemorrhage.
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| DDx:
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| *[[Metaplastic breast carcinoma]].
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| *Fibromatosis.
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| *[[Leiomyoma]] of the breast.
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| *[[Nodular fasciitis]].
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| *[[Phyllodes tumour]].
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| ====Images====
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| <gallery>
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| Image:Mammary_myofibroblastoma_-_low_mag.jpg | Mammary myofibroblastoma - low mag. (WC/Nephron)
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| Image:Mammary_myofibroblastoma_-_intermed_mag.jpg | Mammary myofibroblastoma - intermed. mag. (WC/Nephron)
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| Image:Mammary_myofibroblastoma_-_high_mag.jpg | Mammary myofibroblastoma - high mag. (WC/Nephron)
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| </gallery>
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| www:
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| *[http://path.upmc.edu/cases/case249.html Mammary myofibroblastoma - several images (upmc.edu)].
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| ===IHC===
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| Features:<ref name=pmid22096693>{{Cite journal | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month = | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 }}</ref>
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| *CD34 +ve.<ref name=pmid11474286/>
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| *Desmin +ve.<ref name=pmid11474286/>
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| *H-caldesmon +ve.
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| *Actin +ve.
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| *Vimentin +ve.
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| Other
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| *S100 -ve.
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| *Beta-catenin -ve. (???)
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| ==Squamous metaplasia of lactiferous ducts== | | ==Squamous metaplasia of lactiferous ducts== |